脑微出血患者血浆1,25-（OH）2D3,sLRP1水平与头颅SWI影像学特征的相关性  

Study on the Relationship between 1,25-Dihydroxyvitamin D3, Soluble Low Density Lipoprotein Receptor Related Protein 1 and the SWI Imaging Features of Cerebral Microbleeds

作　　者：刘玥[1] 唐鹏[1] 侯辰 张欣[1] LIU Yue;TANG Peng;HOU Chen;ZHANG Xin(the Third Department of Neurology,Shaanxi Provincial People’sHospital,Xi’an 710068,China)

机构地区：[1]陕西省人民医院神经内三科

出　　处：《现代检验医学杂志》2019年第5期19-22,共4页Journal of Modern Laboratory Medicine

基　　金：陕西省卫生健康科研基金(2018D023,2018D024);陕西省重点研发计划2018SF-028

摘　　要：目的研究脑微出血(cerebral microbleeds,CMBs)患者1,25-二羟维生素D3[1,25-dihydroxyvitamin D3,1,25-(OH)2D3],可溶性低密度脂蛋白受体相关蛋白1(soluble low density lipoprotein receptor related protein 1,sLRP1)水平与头颅SWI微出血病灶数量及部位等影像学特征的相关关系。方法连续纳入2017年1月~2019年5月就诊于陕西省人民医院的CMBs患者196例(男性152例,女性44例),正常对照组99例(男性67例,女性32例),采集人口学资料及病史。对两组人群进行血浆1,25-(OH)2D3,sLRP1水平的检查。比较两组间血浆1,25-(OH)2D3和sLRP1水平的差异,并统计CMBs组各检验指标与CMBs病灶数量及部位的相关关系。结果CMBs组患者血浆1,25-(OH)2D3,sLRP1水平均低于对照组(23.32±18.91 mmol/L vs 39.60±18.58 mmol/L;237.96±70.62 ng/ml vs 312.61±62.78 ng/ml),差异均具有统计学意义(t=7.07,-9.24,均P<0.01)。CMBs患者血浆sLRP1水平与脑皮质CMBs病灶数量呈负相关(r=0.239,P=0.001),而与脑深部CMBs病灶数量无明显相关(t=-0.096,P>0.05)。结论CMBs患者的血浆1,25-(OH)2D3,sLRP1水平均低于正常人群。高表达的血浆sLRP1可能对脑皮质CMBs的发生具有一定的保护作用。Objective The purpose of this study was to investigate the relationship between low density lipoprotein receptor related protein 1(sLRP1),1,25-dihydroxyvitamin D3[25-(OH)2D3]of hemoglobin and cerebral microbleeds in patients.Methods From January 2017 to May 2019,196 CMBs patients(152 males and 44 famales)and 99 normal control patients(67 males and 32 famales)admitted to Shaanxi Provincial People's Hospital were consecutively.Demographic data and medical history were collected,plasma levels of 1,25-(OH)2D3 and sLRP1 were examined in both groups.The differences in plasm levels of 1,25-(OH)2D3 and sLRP1 between the two groups were compared,and the correlation between eath test index and the number and location of CMBs diseases in the CMBs group was calculated.Results The plasma levels of 1,25-(OH)2D3 and sLRP1 in the CMBs group were lower than those in the control group(23.32±18.91 mmol/L vs 39.60±18.58 mmol/L;237.96±70.62 ng/ml vs 312.61±62.78 ng/ml,respectively),and the differences were statistically significant(t=7.07,-9.24,all P<0.01).Plasma sLRP1 levels of CMBs patients were negatively correlated with the number of CMBs lesions in the cerebral cortex(r=0.239,P=0.001),but not significantly correlated with the number of CMBs lesions in the deep brain(t=-0.096,P>0.05).Conclusion The levels of 1,25-(OH)2D3 and sLRP1 in CMBs were lower than those in normal control group.High levels of sLRP1 may protect against the happens of CMBs in the cortex.

关 键 词：脑微出血 可溶性低密度脂蛋白受体相关蛋白1 1 25-二羟维生素D3 

分 类 号：R743.34[医药卫生—神经病学与精神病学] R446[医药卫生—临床医学]