纳米技术改性口腔种植体的研究进展  

Research Progress of Nano-Modified Dental Implants

作　　者：杨雨青 曹志炜 巫佩瑶 周陶 解亮 YANG Yuqing;CAO Zhiwei;WU Peiyao;ZHOU Tao;XIE Liang(West China College of Stomatology,State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西口腔医学院口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心

出　　处：《医学综述》2019年第18期3627-3633,3640,共8页Medical Recapitulate

基　　金：国家自然科学基金青年基金(81600842)

摘　　要：口腔种植技术是牙列缺损及牙列缺失的重要修复方式之一,可以良好恢复牙列的形态、功能及整体美观。但种植体周围骨整合的缺乏、周围骨吸收及相关感染等问题均可能导致植入物松动、治疗失败,限制了种植治疗的进一步应用与推广。近年来,随着纳米技术快速发展,其在生物医学领域中已有广泛应用,学者们通过表面涂层、图案化等多种方式对种植体进行纳米层面的表面改性和(或)本体改性,以提高种植体表面积及表面活性,促进骨整合相关蛋白、细胞的黏附、定植,改善种植体的机械性能、理化性能及生物学性能。Implant prothesis is now a frequently used treatment in prosthodontics,which can restore the morphology,function and aesthetic. However,there are crucial issues that result in failure sometimes: implant-related infection,the lack of implant-bone integration and bone resorption,which limit the further application and promotion of the therapy. Nanotechnology,with its rapid development,has been widely applied in biomedicine,and scholars modify the surface and/or bulk of implants by means of surface coating and patterning,in order to improve the surface area and surface activity of implants,promote the adhesion and colonization of osteointegration-related proteins and cells,and improve the mechanical,physical,chemical and biological properties of implants.

关 键 词：口腔种植体 纳米结构 表面改性 成骨特性 抗菌性 

分 类 号：R783.1[医药卫生—口腔医学]