Ketone Synthesis by Direct, Orthogonal Chemoselective Hydroacylation of Alkenes with Amides: Use of Alkenes as Surrogates of Alkyl Carbanions  

作　　者：Hui Geng Pei-Qiang Huang 

机构地区：[1]Department of Chemistry,Fujian Provincial Key Laboratory of Chemical Biology,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen,Fujian 361005,China

出　　处：《Chinese Journal of Chemistry》2019年第8期811-816,共6页中国化学（英文版）

基　　金：support provided by the National Key R&D Program of China (No.2017YFA0207302);the National Natural Science Foundation of China (Nos.21672176 and 21332007).

摘　　要：Summary of main observation and conclusion Direct functionalization of alkenes and direct transformation of carboxamides are two exciting areas that have attracted considerable attention in recent years.We report herein that secondary amides,the least reactive derivatives of carbonyl compounds,upon activated with triflic anhydride,can serve as effective hydroacylating reagents in partner with alkenes to yield ketones at ambient temperature.The method was applied to the one-step synthesis of racemic dihydro-ar-turmerone.In this method,alkenes serve as surrogates of organometallic reagents,which allows the orthogonal chemoselective reactions.The ready availability of many olefins such as camphene and norbornene permits one-step ketone synthesis that would require several steps by conventional methods.

关 键 词：ALKENES AMIDES ALKYL CARBANIONS 

分 类 号：O6[理学—化学]