脑小血管病与急性缺血性卒中静脉溶栓后出血性转化的关系研究进展  

Recent advances in the relationship between cerebral small vessel disease and hemorrhagic transformation after intravenous thrombolysis in acute ischemic stroke

作　　者：张诗煜 田力[2] 李进伟[1] 滕伟禹[1] Zhang Shiyu;Tian Li;Li Jinwei;Teng Weiyu(Department of Neurology, the First Affiliated Hospital of China Medical Universityt Shenyang 110001,China;Department of Gerontology, Shengjing Hospital Affiliated to China Medical University Shenyang 110004, China)

机构地区：[1]中国医科大学附属第一医院神经内科,沈阳110001 [2]中国医科大学附属盛京医院老年病科,沈阳110004

出　　处：《中华神经科杂志》2019年第9期776-780,共5页Chinese Journal of Neurology

基　　金：国家科技部十三五重大专项项目(2017ZX10201101);中国医科大学2018年度临床医学重大专项建设计划项目(111-3110118036).

摘　　要：脑小血管病是指由于各种病因影响脑内小动脉、微动脉、毛细血管、微静脉和小静脉所导致的一系列临床、影像、病理综合征,从而使脑组织产生缺血或出血性损害.目前静脉溶栓治疗是治疗急性缺血性卒中的首选治疗方案,但大量研究表明,急性缺血性卒中发生前存在脑小血管病将增加静脉溶栓出血转化的风险.文中从脑小血管病不同影像分型角度对脑小血管病与急性缺血性卒中静脉溶栓后出血转化的关系研究进展做一综述,旨在为临床静脉溶栓治疗提供新的参考.Cerebral small vessel disease refers to a series of clinical, imaging and pathological syndromes caused by various diseases affecting small arteries, arterioles, capillaries, venules, and venules in the brain, thereby causing ischemia or hemorrhage in brain tissue. At present, intravenous thrombolytic therapy is the first choice for the treatment of acute ischemic stroke, however a large number of studies have shown that the presence of cerebral small vessel disease before acute ischemic stroke increases the risk of intravenous thrombolysis. In this article, the recent research progresses about the relationship between cerebral small vessel disease and hemorrhagic transformation after venous thrombolysis in acute ischemic stroke are reviewed, aiming to provide a new reference for clinical intravenous thrombolytic therapy.

关 键 词：脑小血管病 卒中 静脉溶栓 出血性转化 

分 类 号：R743.3[医药卫生—神经病学与精神病学]