自噬与炎症性疾病的相互作用与关系  

Advances in autophagy-related genes in inflammatory diseases

作　　者：王雪松[1] 寿松涛[1] 姚咏明[2] WANG Xue-song;SHOU Song-tao;YAO Yong-ming(Emergency Department, General Hospital of Tianjin Medical University, Tianjin 300052, China;Trauma Research Center, the Fourth Medical Center of Chinese PLA General Hospital, Beijing 100048, China)

机构地区：[1]天津医科大学总医院急诊医学科,天津300052 [2]解放军总医院第四医学中心创伤研究中心,北京100048

出　　处：《解放军医学杂志》2019年第9期778-781,共4页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金(81730057,81842025);国家重点研发计划项目(2017YFC1103302)~~

摘　　要：自噬是生物体维持细胞内环境稳态、进化上高度保守的重要的生理生化过程。自噬广泛参与多种疾病的发生发展过程,其与炎症性疾病的相互作用是近年研究的热点。自噬相关基因(ATGs)参与自噬的多个环节,对自噬发挥着重要的调节作用,也影响着炎症性疾病的进程和转归。该文综述自噬及其重要ATGs在炎症性疾病中的调节作用和机制,为研究炎症性疾病的发病机制和调控途径提供新的思路。Autophagy is a highly conserved physiological and biochemical process in which organisms maintain homeostasis of the cellular environment. Autophagy is widely involved in the occurrence and development of many diseases, especially in inflammatory diseases, which is a hot topic in recent years. Autophagy-related genes(ATGs) play important roles in regulating autophagy in many aspects, thus affecting the process and prognosis of inflammatory diseases. This article reviews the regulatory roles and mechanisms of autophagy in inflammatory diseases, as well as the functions and roles of several important ATGs in inflammatory diseases.

关 键 词：自噬 炎症性疾病 自噬相关基因 

分 类 号：R364.5[医药卫生—病理学] Q255[医药卫生—基础医学]