吡咯烷酰胺催化剂的合成及其催化下的不对称Michael反应  

Michael addition Reaction Catalysized by Pyrrolidine Amide

作　　者：钟瑞昕 李淼 陈治明[2] Zhong Ruixin;Li Miao;Chen Zhiming(Guiyang City First Middle School,Guiyang 5500082;School of Chemistry and Materials Science,GuizhouNormal University,Guiyang 550001,China)

机构地区：[1]贵阳一中,贵州贵阳550008 [2]贵州师范大学化学与材料科学学院,贵州贵阳550001

出　　处：《广东化工》2019年第17期82-84,共3页Guangdong Chemical Industry

基　　金：国家自然科学基金资助项目(21362006)

摘　　要：本文成功合成了5种吡咯烷酰胺有机小分子催化剂(1a^1e),将其用于硝基烯烃衍生物的不对称Michael加成反应中。研究表明:35℃下二氯甲烷作为溶剂,吲哚与硝基苯乙烯的摩尔比为1︰1、催化剂1e为最优催化剂、反应12h,得到较高的产率(91%)和ee值(94%)。该反应具有催化剂经济易得、反应条件温和、环境友好和操作简单等优点。In this paper,five kinds of pyrrolidine amide organic small molecule catalysts have been successfully synthesized and used in the Michael addition reaction of nitrostyrene derivatives.The results showed that using dichloromethane as solvent at 35 ℃,the molar ratio of indole and nitrostyrene derivatives is 1 ︰1, the dosage of catalyst is 10 mmol%,the time of reaction is 12 h,the target products can be obtained with higher yield (up to 91 %) and better enantioselectivities(up to 94 % ee).

关 键 词：有机催化剂 吲哚 硝基苯乙烯 MICHAEL加成反应 

分 类 号：O621[理学—有机化学]