Dental remineralization via poly(amido amine) and restorative materials containing calcium phosphate nanoparticles  

作　　者：Kunneng Liang Suping Wang Siying Tao Shimeng Xiao Han Zhou Ping Wang Lei Cheng Xuedong Zhou Michael D.Weir Thomas W.Oates Jiyao Li Hockin H.K.Xu 

机构地区：[1]State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics,West China Hospital of Stomatology,Sichuan University,Chengdu,China [2]Department of Advanced Oral Sciences and Therapeutics,University of Maryland School of Dentistry,Baltimore,MD,USA [3]Department of Operative Dentistry and Endodontics & Stomatology Center,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,China [4]Center for Stem Cell Biology & Regenerative Medicine,University of Maryland School of Medicine,Baltimore,MD,USA [5]Marlene and Stewart Greenebaum Cancer Center,University of Maryland School of Medicine,Baltimore,MD,USA

出　　处：《International Journal of Oral Science》2019年第3期180-191,共12页国际口腔科学杂志（英文版）

基　　金：supported by National Natural Science Foundation of China (81670977, J.L. and 81800965, K.L.);Sichuan Science and Technology program (Grant no. 2017SZ0030);Fundamental Research Funds for Central University 2018SCU12016 (K.L.);China Postdoctoral Science Grant 2018M643507 (K.L.);Research Fund of West China Hospital WCHS-201705 (K.L.);Research Fund for Resins of Chinese Stomatological Association CSA-R2018-06 (K.L.);University of Maryland School of Dentistry bridging fund (H.H.K.X.);University of Maryland Baltimore seed grant (H.H.K.X.)

摘　　要：Tooth decay is prevalent,and secondary caries causes restoration failures,both of which are related to demineralization.There is an urgent need to develop new therapeutic materials with remineralization functions.This article represents the first review on the cutting edge research of poly(amido amine)(PAMAM) in combination with nanoparticles of amorphous calcium phosphate (NACP).PAMAM was excellent nucleation template,and could absorb calcium (Ca) and phosphate (P) ions via its functional groups to activate remineralization.NACP composite and adhesive showed acid-neutralization and Ca and P ion release capabilities.PAMAM +NACP together showed synergistic effects and produced triple benefits: excellent nucleation templates,superior acidneutralization,and ions release.Therefore,the PAMAM+NACP strategy possessed much greater remineralization capacity than using PAMAM or NACP alone.PAMAM+NACP achieved dentin remineralization even in an acidic solution without any initial Ca and P ions.Besides,the long-term remineralization capability of PAMAM+NACP was established.After prolonged fluid challenge,the immersed PAMAM with the recharged NACP still induced effective dentin mineral regeneration.Furthermore,the hardness of predemineralized dentin was increased back to that of healthy dentin,indicating a complete remineralization.Therefore,the novel PAMAM+NACP approach is promising to provide long-term therapeutic effects including tooth remineralization,hardness increase,and caries-inhibition capabilities.Tooth decay is prevalent, and secondary caries causes restoration failures, both of which are related to demineralization. There is an urgent need to develop new therapeutic materials with remineralization functions. This article represents the first review on the cutting edge research of poly(amido amine)(PAMAM) in combination with nanoparticles of amorphous calcium phosphate(NACP).PAMAM was excellent nucleation template, and could absorb calcium(Ca) and phosphate(P) ions via its functional groups to activate remineralization. NACP composite and adhesive showed acid-neutralization and Ca and P ion release capabilities. PAMAM+NACP together showed synergistic effects and produced triple benefits: excellent nucleation templates, superior acidneutralization, and ions release. Therefore, the PAMAM+NACP strategy possessed much greater remineralization capacity than using PAMAM or NACP alone. PAMAM+NACP achieved dentin remineralization even in an acidic solution without any initial Ca and P ions. Besides, the long-term remineralization capability of PAMAM+NACP was established. After prolonged fluid challenge, the immersed PAMAM with the recharged NACP still induced effective dentin mineral regeneration. Furthermore, the hardness of predemineralized dentin was increased back to that of healthy dentin, indicating a complete remineralization. Therefore, the novel PAMAM+NACP approach is promising to provide long-term therapeutic effects including tooth remineralization, hardness increase,and caries-inhibition capabilities.

关 键 词：an URGENT need calcium PHOSPHATE DENTIN 

分 类 号：R[医药卫生]