乳腺癌患者手术前后外周血CD4^+和CD8^+及Treg细胞的表达及临床意义  

Expression and clinical significance of CD4^+ and CD8^+ and Treg cells in peripheral blood of patients with breast cancer before and after operation

作　　者：林永忠 陈榕[2] 钱之远 陈夏[3] 谢树贤 Lin Yongzhong;Chen Rong;Qian Zhiyuan;Chen Xia;Xie Shuxian(Department of Breast and Thyroid Surgery, Fuzhou Traditional Chinese Medicine Hospital, Fuzhou, Fujian, 350001, China;Department of General Surgery, Fuzhou Second HospitalAffiliated to Xiamen University, Fuzhou, Fujian, 350007, China;Department of Breast Surgery, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, 350001, China)

机构地区：[1]福州市中医院乳腺甲状腺外科,福建福州350001 [2]厦门大学附属福州市第二医院普通外科,福建福州350007 [3]福建省肿瘤医院乳腺外科,福建福州350001

出　　处：《当代医学》2019年第29期78-81,共4页Contemporary Medicine

摘　　要：目的观察手术前后乳腺癌患者体内血CD4+T细胞、CD8+T细胞和Treg细胞的表达及临床意义。方法选择2016年1月至2018年8月本院收治的原发性乳腺癌患者83例为病例组,检测其术前、术后外周血CD4^+T细胞、CD8^+T细胞和Treg细胞的变化,同时选取60例健康成年妇女作为对照组,检测其外周血中CD4+T细胞、CD8^+T细胞和Treg细胞的表达情况。分析CD4^+T细胞、CD8^+T细胞和Treg细胞的变化与临床病理参数的关系。结果与对照组相比,乳腺癌患者术前CD4^+T细胞、Treg细胞明显增加,差异有统计学意义(P<0.05);与Ⅰ期患者相比,Ⅱ~Ⅲ期患者术前CD4^+T细胞、Treg细胞增加更明显,差异有统计学意义(P<0.05);乳腺癌患者术后CD4^+T细胞含量降低、CD8^+T细胞含量增加,差异有统计学意义(P<0.05)。结论外周血Treg细胞、CD4+T细胞和CD8^+T细胞水平对于乳腺癌的诊断和预后有一定价值,值得进行深入探讨并将其应用于临床。手术切除肿瘤可在一定程度上改善机体免疫状态,对预后产生积极作用。Objective To observe the expression and clinical significance of blood CD4^+ T cells, CD8^+ T cells and Treg cells in breast cancer patients before and after operation. Methods From January 2016 to August 2018, 83 patients with primary breast cancer in our hospital were selected as the case group. The changes of peripheral blood CD4^+ T cells, CD8^+ T cells and Treg cells were measured before and after surgery. 60 cases of healthy adult women were used as a control group to detect the expression of CD4^+ T cells, CD8^+ T cells and Treg cells in peripheral blood. The relationship between changes in CD4^+ T cells, CD8^+ T cells and Treg cells and clinicopathological parameters was analyzed. Results Compared with the control group, preoperative CD4^+ T cells and Treg cells were significantly increased in breast cancer patients, the difference was statistically signifi- cant (P<0.05);Compared with stage I patients, preoperative CD4^+ T cells and Treg cells increased significantly in patients with stage Ⅱ-Ⅲ, and the difference was statistically significant (P<0.05);The content of CD4^+ T cells and the content of CD8^+ T cells in breast cancer patients increased, the difference was statistically significant (P<0.05). Conclusion The levels of peripheral blood Treg cells, CD4^+ T cells and CD8^+ T cells have certain value for the diagnosis and prognosis of breast cancer, and it is worthy of further study and application in clinical. Surgical resection of the tumor can improve the immune status of the body to a certain extent, and has a positive effect on the prognosis.

关 键 词：乳腺癌 CD4^+T细胞 CD8^+T细胞 TREG细胞 

分 类 号：R737.9[医药卫生—肿瘤]