动态对比增强磁共振成像定量参数直方图分析与鼻咽癌临床分期的相关性初步研究  

Preliminary study on the relationship between histogram analysis of DCE-MRI quantitative parameters and clinical stage of nasopharyngeal carcinoma

作　　者：高欣 周丽娟[2] 徐孝秋[2] 沈小红[2] 邹莉[3] 武江芬 沈钧康[2] GAO Xin;ZHOU Lijuan;XU Xiaoqiu;SHEN Xiaohong;ZOU Li;WU Jiangfen;SHEN Junkang(Department of Radiology,Suzhou Dushuhu Public Hospital,Suzhou 215124,China;Dpeartment of Radiotherapy,the Second Affiliated Hospital of Soochozv University,Suzhou 215000,China;Department of Radiotherapy,the Second Affiliated Hospital of Soochozv University,Suzhou 215000,China;GE Healthcare Life Sciences,Shanghai 201203,China)

机构地区：[1]苏州市独墅湖医院放射科,江苏苏州215124 [2]苏州大学附属第二医院影像科,江苏苏州215000 [3]苏州大学附属第二医院放疗科,江苏苏州215000 [4]通用电气医疗集团生命科学部,上海201203

出　　处：《实用放射学杂志》2019年第10期1590-1594,共5页Journal of Practical Radiology

摘　　要：目的探讨鼻咽癌(NPC)DCE-MRI定量参数直方图分析与临床分期的相关性。方法对70例经病理证实的NPC患者行MRI检查并分期,用全容积ROI设置法对NPC癌灶进行测量,对得到的DCE-MRI定量参数行直方图分析。采用Spearman相关分析评价DCE-MRI定量参数直方图分析结果与NPC临床分期的相关性。结果全容积直方图分析的转运常数(Ktrans)值的平均数、10%位数、75%位数、90%位数、速率常数(Kep)值的平均数、10%位数、峰度及血管外细胞外间隙体积百分比(Ve)值的平均数、90%位数、偏度与T分期相关(P均<0.05),其中Ktrans值75%位数的Spearman相关系数最大。Ktrans值的平均数及Ve值的平均数、90%位数与N分期相关(P均<0.05),其中Ve值90%位数的Spearman相关系数最大。Kep值的峰度及Ve值的平均数与M分期相关(P均<0.05)。全容积直方图分析结果显示Kep各参数值与N分期无相关性,Ktrans各参数值与M分期无相关性。Ktrans值的平均数、10%位数、75%位数、90%位数、Kep值的10%位数、75%位数、峰度及Ve值的平均数、75%位数、90%位数与临床总分期相关(P均<0.05),其中Ve值90%位数的Spearman相关系数最大。结论 DCE-MRI定量参数全容积直方图分析结果显示多个参数与NPC临床分期存在相关性;可以多参数、无创地反映NPC的侵袭性、疾病进展,对NPC的临床分期具有一定的指导作用,为治疗方案的制订提供潜在依据。Objective To investigate the relationship between histogram analysis of DCE-MRI quantitative parameters and clinical stage of nasopharyngeal carcinoma (NPC). Methods 70 patients with NPC confirmed by pathology underwent MR1 examination and staging.NPC tumors were measured by full-volume ROI setting method,and the obtained DCE-MRI quantitative parameters were analyzed by histogram.Spearman correlation coefficients were obtained to evaluate the potential correlation between the IX'E-MRI histogram quantitative parameters and NPC clinical stages.Results The histogram-based Ktrans(mean, 10 th,75 th,90 th),Kn,(mean, 10 th,kurtosis),and Vc (mean, 90 th, skewness) had correlation with T stage ( P < 0.05, respectively). The histogram-based Ktraans(mean) and Ve (mean, 90 th) showed correlation with N stage ( P<0.05 , respectively).The histogram-based Kep(kurtosis) and Ve(mean) had correlation with M stage ( P<0.05,respectively).The histogram-based Krp had no correlation with N stage,and Ktrans had no correlation with M stage. The histogram-based Ktrans(mean, 10th,75 th,90 th),Kep(10 th,75 th,kurtosis) and Vc(mean,75 th,90 th) had correlation with overall stage (P<0.05,respectively). Conclusion The histogram analysis of DCE-MRI quantitative parameters showed that the multiple parameters associated with NPC overall stages.DCE-MRI quantitative parameters non-invasively reflect the aggressiveness and progression of NPC.The histogram analysis of DCE-MRI quantitative parameters may play a role in clinical stage of NPC.

关 键 词：乳腺癌 动态对比增强磁共振成像 扩散加权成像 术前诊断 

分 类 号：R737.9[医药卫生—肿瘤] R445.2[医药卫生—临床医学]