Hepassocin:一种新型的肝细胞因子  

Hepassocin:a novel hepatokine

作　　者：吕枭锐 龚凤英[1] Lv Xiaorui;Gong Fengying(Department of Endocrinology,Key Laboratory of Endocrinology of National Health Commission,The Translational Medicine Center of PUMCH,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院,中国协和医科大学,北京协和医院内分泌科,卫健委内分泌重点实验室,协和转化医学中心,北京100730

出　　处：《国际内分泌代谢杂志》2019年第5期332-336,共5页International Journal of Endocrinology and Metabolism

基　　金：北京市自然科学基金(7182130,7082079);国家自然科学基金(81370898,30771026,30540036);人社部留学人员科技活动项目择优资助经费(启动类);国家临床重点专科建设项目单位(WBYZ2011-873).

摘　　要：Hepassocin(HPS)是一种肝细胞特异性分泌的蛋白质.研究发现,HPS能促进正常肝细胞增殖,抑制肝癌细胞增殖.HPS在急性肝损伤时能通过抑制肝细胞凋亡保护肝脏,并具有减轻高血糖所导致的肝细胞氧化应激的作用.在非酒精性脂肪性肝病(NAFLD)患者中,HPS的表达和分泌增多,其能诱导肝脂质合成和聚集.而在2型糖尿病患者中,血浆HPS浓度显著增加,与肝脏和骨骼肌等组织、器官的胰岛素抵抗有关.这些研究表明,HPS不仅可以调控肝细胞增殖和凋亡,还能参与NAFLD和2型糖尿病的发生、发展.Hepassocin ( HPS ) is a hepatocyte-specific secreted protein. Studies found that HPS could promote the proliferation of normal hepatocytes, whereas inhibited the proliferation of liver cancer cells. It can protect the liver through inhibition of hepatocytes apoptosis in the case of acute liver injury, and improve oxidative stress induced by hyperglycemia in hepatocytes. The expression and secretion of HPS are significantly increased in patients with nonalcoholic fatty liver disease ( NAFLD), and it can induce produc-tion and aggregation of liver fat. In addition, the plasma concentration of HPS is significantly increased in patients with type 2 diabetes, and it induces insulin resistance of liver and skeletal muscle tissues. These studies indicate that HPS is not only involved in the proliferation and apoptosis of hepatocytes, but also the development of NAFLD and diabetes.

关 键 词：Hepassocin 肝细胞增殖 非酒精性脂肪性肝病 胰岛素抵抗 2型糖尿病 

分 类 号：R575[医药卫生—消化系统] R587.1[医药卫生—内科学]