p53蛋白异常与肿瘤发生关系的研究进展  

Progress of the relationship between aberrant p53 protein and tumorigenesis

作　　者：许杰 郝牧[1] Xu Jie;Hao Mu(State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300020, China)

机构地区：[1]中国医学科学院北京协和医学院血液学研究所血液病医院实验血液学国家重点实验室,天津300020

出　　处：《肿瘤研究与临床》2019年第9期633-636,共4页Cancer Research and Clinic

基　　金：国家自然科学基金(81630007、81570181).

摘　　要：TP53基因是迄今发现与人类肿瘤相关性最高的基因,在大约50%的恶性肿瘤中发生突变,其编码的p53蛋白是体内的抑癌因子,与肿瘤的发生息息相关。研究发现,肿瘤的发生与多种生物学过程异常有密切关系,主要包括细胞周期调控、细胞凋亡、DNA损伤修复、细胞衰老、自噬、代谢调节等方面。文章从影响肿瘤发生的各生物学过程的角度来阐述p53蛋白与肿瘤发生之间复杂的网络关系。TP53 gene has been found to have the highest correlation with human tumors, and its mutations occurr in about 50% malignant tumors. Its encoded p53 protein is a well-known tumor-suppressor factor in vivo, which is closely related to tumorigenesis. It is found that tumorigenesis has a close relationship with various abnormal biological processes, including cell cycle regulation, apoptosis, DNA damage repair, cell senescence, autophagy, metabolic regulation. This paper reviews the complex network relationship between p53 protein and tumorigenesis from biological processes affecting the tumorigenesis.

关 键 词：肿瘤 肿瘤抑制蛋白质P53 生物学过程 

分 类 号：R730.2[医药卫生—肿瘤]