负载黄芪多糖的Span-PEG微泡的抑菌和超声造影效果  

Bacteriostatic and Sonographic Effects of Span-PEG Microbubbles Loaded with Polysaccharose

作　　者：宋立梅 张杰[1] 张慧明[1] 王欣[1] 焦玉凤[1] SONG Li-mei;ZHANG Jie;ZHANG Hui-ming;WANG Xin;JIAO Yu-feng(Jiamusi University, Heilongjiang, Jiamusi 154007, China)

机构地区：[1]佳木斯大学

出　　处：《精细化工中间体》2019年第4期31-34,共4页Fine Chemical Intermediates

基　　金：国家自然科学基金(81601616);黑龙江省省属本科高校基本科研业务费优秀创新团队建设项目(2018-KYYWF-0914);黑龙江省自然科学基金(E2017063);佳木斯大学大学生创新创业项目(2019xj05)

摘　　要：利用声振空化法制备负载黄芪多糖的Span-PEG微泡,考察其抑菌以及超声成像效果.实验结果表明,所制备的Span-PEG复合微泡平均粒径为595.3 nm、Zeta电位为-18.8 mV,Span-PEG复合微泡中黄芪多糖负载率为(8.60±0.24)%.Span-PEG复合微泡对大肠杆菌和金黄色葡萄球菌具有抑菌作用,且效果随Span-PEG复合微泡浓度的增加而增强.Span-PEG复合微泡在家兔体内心脏、肾脏和子宫均具有显著的超声显影效果.Span-PEG microbubbles loaded with the astragalus polysaccharide were prepared by acoustic cavitation method. Its effects on the bacteriostatic and ultrasonic imaging were investigated. The experimental results showed that: the average particle size of the Span-PEG composite microbubbles was 595.3 nm, the Zeta potential was -18.8 mV;and the load rate of astragalus polysaccharide in the Span-PEG composite microbubbles was (8.60±0.24)%;Span-PEG composite microbubbles had the bacteriostatic effect on escherichia coli and staphylococcus aureus, and the bacteriostatic effect increased with the increase of the Span -PEG composite microbubbles concentration;the Span -PEG composite microbubbles have significant ultrasonic imaging effect on the heart, kidney and uterus in rabbits.

关 键 词：黄芪多糖 超声造影剂 抑菌 超声成像 

分 类 号：R313[医药卫生—基础医学]