低氧诱导因子的调控途径和在肠道疾病中的作用  

Regulatory pathway of hypoxia-inducible factor and its role in intestinal diseases

作　　者：滕文彬 李玉红[1,2] 祝胜美 TENG Wen-bin;LI Yu-hong;ZHU Sheng-mei(Department of Anesthesiology,Zhejiang University,Shaoxing 312000,China;Medical Research Center,Shaoxing Hospital,Zhejiang University,Shaoxing 312000,China;Department of Anesthesiology,The First Affiliated Hospital,Zhejiang University,Hangzhou 310000,China)

机构地区：[1]浙江大学绍兴医院麻醉科,浙江绍兴312000 [2]浙江大学绍兴医院医学研究中心,浙江绍兴312000 [3]浙江大学附属第一医院麻醉科,浙江杭州310000

出　　处：《中国病理生理杂志》2019年第10期1894-1900,共7页Chinese Journal of Pathophysiology

基　　金：浙江省公益技术应用研究计划项目(No.LGF19H030011);浙江省医药卫生科技计划项目(No.2018KY173);绍兴市科技计划项目(No.2017B70038)

摘　　要：肠道上皮覆盖着整个胃肠道系统,在成人有大约300平方米的表面积,形成了通往外部的重要屏障,在维持内环境和体内外的平衡起着至关重要的作用。肠道上皮不仅对营养物质的吸收和对非致病性抗原耐受性的形成起着重要作用,同时也受到氧供的调节。近年来,人们越来越认识到组织氧代谢是维持肠道上皮内环境稳态的关键。正常肠道上皮处于"生理性缺氧"的环境,由于逆流血流和大量细菌的存在,肠道基线动脉氧分压水平低于正常值。Intestinal tract is the largest organ of the human body. It plays an important role in the absorption of nutrients and the resistance to pathogens. At the same time, it is also regulated by oxygen supply. Hypoxia-inducible factor(HIF) is a key factor in the regulation of hypoxia and plays a key role in maintaining the homeostasis of the intestinal environment. In the development of inflammatory bowel disease, intestinal tumor, ischemia-perfusion injury and intestinal flora imbalance, HIF responds to inflammation and hypoxia, and causes an important adaptive response in intestinal mucosa, thus maintaining the function of the intestinal epithelium or promoting the development of intestinal tumors. In this review, the recent advances in HIF structure, function and regulatory pathways, and its role in intestinal diseases are reviewed.

关 键 词：低氧诱导因子 调节途径 肠道疾病 

分 类 号：R574[医药卫生—消化系统] R363[医药卫生—内科学]