宫颈癌患者岩藻糖基转移酶4的表达特点及与介入治疗预后的关系  

Expression of fucoidyltransferase 4 in cervical cancer and its relationship with prognosis after interventional therapy

作　　者：胡睿[1] 王映霞[1] 阳光辉[1] 李青春[1] 黄婷[1] 唐圣魏 HU Rui;WANG Yinxia;YANG Guanghui;LI Qingchun;HUANG Ting;TANG Shenwei(Department of Radiology,Hu′nan Maternal and Child Health Care Hospital,Hu′nan Province,Changsha 410008,China)

机构地区：[1]湖南省妇幼保健院放射科

出　　处：《中国医药导报》2019年第26期89-92,共4页China Medical Herald

基　　金：湖南省卫生计生委科研计划课题项目（C2017056）

摘　　要：目的探讨宫颈癌患者岩藻糖基转移酶4 (FUT4)的表达特点及与介入治疗预后的相关性。方法选取2012年2月~2017年2月在湖南省妇幼保健院治疗的宫颈癌患者74例(宫颈癌组),均给予介入治疗联合子宫切除术,同时选取因子宫肌瘤行子宫切除患者40例作为对照(对照组)。采用Western blot法检测两组患者FUT4蛋白表达水平,同时随访观察患者预后情况。结果宫颈癌组FUT4蛋白相对表达明显高于对照组,差异有统计学意义(P <0.05);肿瘤直径>4 cm、有淋巴结转移的宫颈癌患者FUT蛋白相对表达明显高于肿瘤直径≤4 cm、无淋巴结转移患者(P <0.05);FUT蛋白表达下调患者中位无疾病进展期和总体生存时间明显高于FUT蛋白表达不变患者和上调患者(P <0.05)。结论宫颈癌患者FUT4蛋白呈高表达,与患者临床病理特征有一定关系;介入治疗后FUT4蛋白表达下调者预后较好。Objective To investigate the clinical significance of expression of fucoidyltransferase 4 (FUT4) in cervical cancer and its relationship with prognosis after interventional therapy. Methods Seventy-four cases of cervical cancer (cervical cancer group) in Hu′nan Maternal and Child Health Care Hospital from February 2012 to February 2017 were selected and treated with interventional therapy combined with hysterectomy, and 40 cases of hysterectomy with hysteromyoma were selected as control (control group), the expression of FUT4 protein was detected by Western blot, and the prognosis of patients was followed up. Results The relative expression of FUT4 protein in cervical cancer cervical cancer group was significantly higher than that in the control group (P < 0.05). The relative expression of FUT protein in patients with tumor diameter > 4 cm and lymph node metastasis were significantly higher than the tumor diameter ≤ 4 cm and no lymph node metastases (P < 0.05). The median duration of disease free progression and the total survival time in down regulation of FUT protein expression patients were higher than those in patients with the invariant and up-regulated expression of FUT protein (P < 0.05). Conclusion FUT4 protein is highly expressed in cervical cancer patients, which is related to the clinicopathological characteristics of patients. Patients with down-regulation of FUT4 protein after interventional therapy has a good prognosis.

关 键 词：岩藻糖基转移酶4 宫颈癌 介入治疗 预后 

分 类 号：R737.33[医药卫生—肿瘤]