羟苯磺酸钙联合降糖药治疗糖尿病视网膜病变伴白内障的临床效果  

Clinical effect of Calcium Dobesilate combined with hypoglycemic agents in the treatment of diabetic retinopathy with cataract

作　　者：郭静 郭靖 陈贺 GUO Jing;GUO Jing;CHEN He(Ophthalmology Department,Yingkou Central Hospital,Liaoning Province,Yingkou 115002,China;Endocrine Department,Yingkou Central Hospital,Liaoning Province,Yingkou 115002,China)

机构地区：[1]辽宁省营口市中心医院眼科,辽宁营口115002 [2]辽宁省营口市中心医院内分泌科,辽宁营口115002

出　　处：《中国医药导报》2019年第26期152-155,171,共5页China Medical Herald

基　　金：辽宁省科技计划项目（2016225026）

摘　　要：目的探讨羟苯磺酸钙联合降糖药治疗糖尿病视网膜病变伴白内障的临床效果。方法选取2016年1月~2018年5月辽宁省营口市中心医院收治的糖尿病视网膜病变伴白内障患者86例(118眼),按随机数字表法将其分为对照组(43例,60眼)和观察组(43例,58眼)。对照组给予常规降糖药治疗,观察组在常规降糖药的基础上联合羟苯磺酸钙治疗。治疗3个月后,比较两组临床疗效及用药不良反应,观察两组治疗前后裸眼视力情况,检测并比较两组血糖指标、血液流变学指标及血管内皮生长因子(VEGF)、缺氧诱导因子(HIF-1α)水平变化。结果观察组临床疗效的总有效率高于对照组,差异有统计学意义(P <0.05)。两组治疗后裸眼视力均较治疗前升高,且观察组高于对照组(P <0.05)。两组治疗后空腹血糖(FBG)、餐后2 h血糖(2h PBG)及糖化血红蛋白(HbA1c)水平均较治疗前降低(P <0.05)。两组治疗后红细胞变形指数、血浆黏度、红细胞聚集指数、血细胞比容及血清VEGF、HIF-1α水平均较治疗前降低(P <0.05),且观察组上述指标均低于对照组(P <0.05)。两组治疗期间未发现明显不良反应。结论常规降糖药联合羟苯磺酸钙治疗糖尿病视网膜病变伴白内障患者效果显著,可有效控制血糖,改善视力,且用药安全。Objective To explore the clinical efficacy of Calcium Dobesilate combined with hypoglycemic agents in the treatment of diabetic retinopathy with cataract. Methods A total of 86 diabetic retinopathy patients (118 eyes) with cataract admitted to Yingkou Central Hospital of Liaoning Province from January 2016 to May 2018 were selected and divided into the control group (43 cases, 60 eyes) and the observation group (43 cases, 58 eyes) according to random number table method. The control group was treated with routine hypoglycemic agents, while the observation group was treated with Calcium Dobesilate on the basis of routine hypoglycemic agents. After 3 months of treatment, the clinical efficacy and adverse drug reactions of the two groups were compared. The naked vision of the two groups before and after treatment was observed, and the blood glucose indexes, hemorheology indexes, the levels of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor (HIF-1α) were detected and compared in the two groups. Results The total effective rate of the clinical efficacy of the observation group was higher than that of the control group, and the difference was statistically significant (P < 0.05). After treatment, the naked vision of both groups was increased compared with that before treatment, and the observation group was higher than the control group (P < 0.05). After treatment, the levels of fasting blood glucose (FBG), 2 h postprandial blood glucose (2hPBG) and glycosylated hemoglobin (HbA1c) in the two groups were reduced compared with those before treatment (P < 0.05). After treatment, erythrocyte deformation index, plasma viscosity, erythrocyte aggregation index, hematocritm, serum VEGF and HIF-1α levels in both groups were reduced compared with those before treatment (P < 0.05), and the above indexes in the observation group were lower than those in the control group (P < 0.05). No adverse reactions were found during treatment in the two groups. Conclusion The combination of routine hypoglycemic agents

关 键 词：糖尿病视网膜病变 白内障 羟苯磺酸钙 血糖 血液流变学 

分 类 号：R779.6[医药卫生—眼科]