丹参注射液辅助常规疗法治疗口腔黏膜下纤维性变的效果及对SFRP1水平的影响  

Effect of conventional treatment assisted by Danshen Injection in the treatment of oral submucous fibrosis and its influence on SFRP1 level

作　　者：肖艳波[1] 谭劲[1] 张琳[1] 李群 左巧娟[1] XIAO Yanbo;TAN Jin;ZHANG Lin;LI Qun;ZUO Qiaojuan(Department of Dental,the First Hospital of Hu′nan University of Chinese Medicine,Hu′nan Province,Changsha 410000,China)

机构地区：[1]湖南中医药大学第一附属医院口腔科

出　　处：《中国医药导报》2019年第25期79-82,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(面上项目)(81874496)

摘　　要：目的探讨丹参注射液辅助常规疗法治疗口腔黏膜下纤维性变(OSF)的效果及对分泌型卷曲相关蛋白1(SFRP1)的影响。方法选取2016年4月~2018年3月湖南中医药大学第一附属医院收治的68例OSF患者,采用随机数字表法将其分为单药组(34例)和联合组(34例)。单药组给予曲安奈德治疗,联合组给予丹参注射液联合曲安奈德治疗。比较两组患者治疗前后的张口度、口腔黏膜病损面积、视觉模拟评分(VAS)、龈沟液及唾液中SFRP1、血清白细胞介素-6(IL-6)、转化生长因子-β1(TGF-β1)的水平和临床效果。结果治疗前两组患者张口度、口腔黏膜病损面积、VAS评分、龈沟液及唾液中SFRP1水平、血清IL-6、TGF-β1水平比较,差异无统计学意义(P>0.05);治疗后,联合组口腔黏膜病损面积、VAS评分低于单药组,张口度高于单药组(P<0.05);联合组龈沟液及唾液中SFRP1均高于单药组(P<0.05);联合组血清IL-6、TGF-β1均低于单药组(P<0.05);联合组治疗效果显著优于单药组(P<0.05)。结论丹参注射液辅助曲安奈德治疗OSF的效果优于单用曲安奈德,能有效升高龈沟液及唾液中SFRP1水平,延缓口腔黏膜下纤维性变的发展进程。Objective To explore the therapeutic effect of conventional treatment assisted by Danshen Injection in the treatment of oral submucous fibrosis (OSF) and the influence on secreted frizzled related protein 1 (SFRP1). Methods A total of 68 patients with OSF admitted to the First Hospital of Hu'nan University of Chinese Medicine from April 2016 to March 2018 were selected and divided into single drug group (34 cases) and combined group (34 cases) by using random number table method. The single drug group was treated with Triamcinolone Acetonide and the combined group was given Danshen Injection combined with Triamcinolone Acetonide. The mouth opening, oral mucosal impairment area, visual anologue scale (VAS), levels of SFRP1 in gingival crevular fluid and saliva, serum interleukin-6(IL-6), transforming growth factor-β1 (TGF-β1) and clinical effect were compared before and after treatment. Results Before treatment, there were no significant differences in oral mucosal impairment area, VAS score, levels of SFRP1, serum IL-6, TGF-β1 in gingival crevular fluid and saliva between the two groups (P>0.05);after treatment, the oral mucosal impairment area and VAS score of the combined group were significantly lower than those of the single drug group and mouth opening was higher than that of the single drug group (P<0.05);levels of SFRP1 in gingival crevicular fluid and saliva in the combined group was higher than that in the single drug group (P<0.05);serum IL-6 and TGF-β1 in the combined group were lower than those in the single drug group (P<0.05);the therapeutic effect of the combined group was significantly better than that of the single drug group (P<0.05). Conclusion The effect of Danshen Injection combined with Triamcinolone Acetonide in the treatment of OSF is better than Triamcinolone Acetonide, which can effectively increase the levels of SFRP1 in gingival crevicular fluid and saliva, and slow down the development of oral submucous fibrosis.

关 键 词：丹参注射液 口腔黏膜下纤维性变 分泌型卷曲相关蛋白1 曲安奈德 

分 类 号：R781.5[医药卫生—口腔医学]