前白蛋白/纤维蛋白原比值与胃癌临床病理特征的关系  

Association of prealbumin/fibrinogen ratio with clinicopathologic characteristics of gastric cancer

作　　者：张俊斌 王浩浩[1] 王伟斌[1] 王海勇[1] 陆轶民[1] 俞雄飞[1] 滕理送[1] Jun-Bin Zhang;Hao-Hao Wang;Wei-Bin Wang;Hai-Yong Wang;Yi-Min Lu;Xiong-Fei Yu;Li-Song Teng(Department of Surgical Oncology,the First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,Zhejiang Province,China)

机构地区：[1]浙江大学医学院附属第一医院肿瘤外科

出　　处：《世界华人消化杂志》2019年第18期1133-1141,共9页World Chinese Journal of Digestology

基　　金：浙江省医药卫生科技计划省部共建重点项目,No.2017209495~~

摘　　要：背景既往研究表明前白蛋白(prealbumin,PA)与纤维蛋白原(fibrinogen,Fib)可用于判断多种恶性肿瘤的临床病理特征及预后.因此本研究推测前白蛋白/纤维蛋白原比值(prealbumin-to-fibrinogen,PA/F)可预测胃癌(gastric cancer,GC)患者临床病理特征,术前辅助判断肿瘤进展程度.目的探讨术前PA与Fib比值PA/F和GC临床病理特征的关系.方法回顾性分析2017-01/2019-03浙江大学附属第一医院肿瘤外科收治的210例GC患者术前临床病理资料并分为低PA/F组和高PA/F组.比较两组临床资料及病理学特征的差异并分析PA/F值与其他预后相关免疫营养指标的相关性.结果PA/F值与年龄、肿瘤大小、分化程度、浸润深度、淋巴结转移、TNM分期和神经血管侵犯相关(P<0.05),低PA/F值组表现出患者年龄更大、肿瘤最大径更大、分化程度更差、浸润深度更深、TNM分期更晚和更易神经脉管侵犯(P<0.05).PA/F值与中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)、血小板与淋巴细胞比值(platelet-to-lymphocyteratio,PLR)、C反应蛋白与白蛋白比值(C-reactiveprotein-to-albumin ratio,CAR)和系统性免疫炎症指数(systemic immune-inflammation index,SII)呈负相关性,与预后营养指数(prognostic nutritional index,PNI)呈正相关性.结论PA/F值可作为GC患者术前临床病理特征的判断指标,其值≤9.07提示肿瘤处于进展期,TNM分期相对较差,PA/F值与NLR、PLR、CAR、SII和PNI多种GC预后指数具有相关性.BACKGROUND Previous studies have shown that prealbumin(PA)and fibrinogen(Fib)can be used to predict the clinicopathological features and prognosis of a variety of malignant tumors.Therefore,we speculated that the prealbumin-to-fibrinogen ratio(PA/F)can predict the clinicopathological features of patients with gastric cancer(GC)and tumor progression preoperatively.AIM To explore the relationship between the PA/F ratio and clinicopathological features of patients with GC.METHODS The preoperative clinical and pathological data of 210 patients with GC admitted to the First Affiliated Hospital of Zhejiang University from January 2017 to March 2019 were retrospectively analyzed.The patients were divided into either a low PA/F group or high PA/F group.The differences in clinical data and pathological features were compared between the two groups,and the correlation between PA/F values and other prognosis-related immunonutrient indicators was also analyzed.RESULTS The PA/F ratio was significantly associated with age,tumor size,degree of differentiation,depth of invasion,lymph node metastasis,TNM stage,and neurovascular invasion(P<0.05).The low PA/F value group showed greater age,larger tumor diameter,lower degree of differentiation,deeper infiltration,advanced TNM stage,and more frequent neurovascular invasion(P<0.05).PA/F values were negatively correlated with multiple immune nutrition indicators,such as neutrophil-tolymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),C-reactive protein-to-albumin ratio(CAR),and systemic immune-inflammation index(SII),but positively CONCLUSION The PA/F ratio can be used as a predictor of preclinical clinicopathological features in patients with GC,and patients with a PA/F ratio≤9.07 have a relatively poor prognosis.The PA/F value is associated with NLR,PLR,CAR,SII,and PNI.

关 键 词：前白蛋白 纤维蛋白原 胃癌 临床病理特征 

分 类 号：R735.2[医药卫生—肿瘤]