滋补肝肾类方联合西药治疗帕金森病临床疗效的Meta分析  

Clinical Efficacy of Nourishing Liver and Kidney Combined with Western Medicine in the Treatment of Parkinson′s Disease:a Meta-analysis

作　　者：张令霖 连新福[2] 徐敏 方格 王彬 李先涛[3] ZHANG Linglin;LIAN Xinfu;XU Min;FANG Ge;WANG Bin;LI Xiantao(Second Institute of Clinical Medicine,Guangzhou University of Chinese Medicine,Guangzhou,Guangdong,China)

机构地区：[1]广州中医药大学第二临床医学院,广州510405 [2]广东省中医院珠海医院 [3]广州中医药大学基础医学院

出　　处：《中西医结合心脑血管病杂志》2019年第18期2737-2743,共7页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：国家重点基础研究发展计划(973计划)项目(No.2014CB542901)

摘　　要：目的评价滋补肝肾类方联合西药治疗帕金森病的临床疗效和安全性。方法计算机检索中国期刊全文数据库(CNKI)、维普数据库(VIP)、万方数据库、中国生物医学数据库(CBM),筛选采用滋补肝肾类方联合西药治疗帕金森病的随机对照试验(RCTs)相关文献,汇总各研究的临床疗效数据,并使用RevMan5.3软件进行Meta分析。结果最终纳入31篇文献,共涉及2320例病人。Meta分析结果显示:滋补肝肾类方联合西药能明显提高帕金森病治疗的总有效率[OR=3.54,95%CI(2.56,4.88),P<0.00001];改善统一帕金森病评分量表(UPDRS、UPDRSⅠ~Ⅳ)评分[WMD=-8.31,95%CI(-9.88,-6.73),P<0.00001;WMD=-0.55,95%CI(-0.86,-0.24),P=0.0005;WMD=-2.74,95%CI(-4.43,-1.06),P=0.001;WMD=-3.00,95%CI(-4.40,-1.61),P<0.0001;WMD=-1.42,95%CI(-2.67,-0.18),P=0.02];改善中医证候评分[WMD=-9.50,95%CI(-12.02,-6.98),P<0.00001];改善韦氏综合评定量表(Webster)评分[WMD=-3.22,95%CI(-4.16,-2.27),P<0.00001];减少不良反应的发生[OR=0.27,95%CI(0.16,0.48),P<0.00001]。结论滋补肝肾类方联合西药治疗帕金森病对比单纯西药治疗有更好的临床疗效。Objective To evaluate the efficacy and safety of Nourishing Liver and Kidney combined with western medicine in treating Parkinson′s disease. Methods Randomized controlled trials (RCTs) about Nourshing Liver and Kidney combined with western medicine in treating Parkinson′s disease were searched in the databases of CNKI,VIP,Wanfang,CBM.The included data was statistically analyzed by using RevMan5.3 software. Results A total of 31 RCTs were included,involving 2 320 patients.Meta-analysis results showed that Nourshing Liver and Kidney combined with western medicine could significantly improve the total curative effect[OR=3.54, 95% CI (2.56,4.88), P <0.000 01];improve UPDRS、 UPDRS I-IV scores[WMD=-8.31,95% CI (-9.88,-6.73), P <0.000 01;WMD=-0.55, 95% CI (-0.86,-0.24), P =0.000 5;WMD=-2.74,95% CI (-4.43,-1.06), P =0.001;WMD=-3.00,95% CI (-4.40,-1.61), P <0.000 1;WMD=-1.42,95% CI (-2.67,-0.18), P =0.02];improve TCM symptom score [WMD=-9.50,95% CI (-12.02,-6.98), P <0.000 01)];improve Webster score[WMD=-3.22,95% CI (-4.16,-2.27), P <0.000 01];Meanwhile,It could reduce the adverse reactions[OR=0.27,95% CI (0.16,0.48), P <0.000 01]. Conclusion Compared with western medicine,the effectiveness of Nourshing Liver and Kidney combined with western medicine in treating Parkinson′s disease was more significant.

关 键 词：帕金森病 滋补肝肾 西药 META分析 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R256.46[医药卫生—临床医学]