脂质体与牙周病的研究进展  

Research progress on liposomes and periodontal disease

作　　者：程国平 丁一[1] 郭淑娟[1] CHENG Guoping;DING Yi;GUO Shujuan(State Key Laboratory of Oral Diseases & National Center for Clinical Research of Oral Diseases & Department of Periodontology & West China Hospital of Stomatology & Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院牙周病科

出　　处：《口腔疾病防治》2019年第10期658-661,共4页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：国家973项目(2013CBA01705-1)

摘　　要：脂质体是类似细胞膜的微球体,具有良好的缓释性、生物相容性和靶向性,并可以降低包封药物毒性等优越性能。本文就脂质体用于牙周药物传递系统和牙周组织工程支架的研究进展进行综述。通过现有研究表明脂质体在牙周药物传递系统方面展现出独特优势和广阔前景,其中载生物活性分子脂质体和牙周组织工程支架结合,可提高其释药动力学和局部疗效,生物支架表面修饰的各种细胞外基质蛋白可促进脂质体吸附于生物支架表面,减少生物活性分子需要量、提高有效转化率和延长体内半衰期。但新型脂质体的研制、临床应用的有效性和安全性评价仍需要进一步深入探究。Liposomes are microspheres that are similar to cell membranes. They have good sustained release, biocompatibility and targeting ability and can reduce the toxicity of encapsulated drugs. This article reviews the research progress of the use of liposomes in periodontal drug delivery systems and periodontal tissue engineering scaffolds. Liposomes have shown unique advantages and broad prospects in the field of periodontal drug delivery. Liposomes loaded with bioactive molecules and combined with periodontal tissue engineering scaffolds can improve the pharmacokinetics and local efficacy of these molecules. Modification of various extracellular matrix proteins on the surface of the scaffolds can promote the absorption of liposomes. Attachment of these proteins to the surface of the scaffold can reduce the requirement for bioactive molecules, improve the effective conversion rate and prolong the half-life of the scaffold in vivo.However, the development, clinical efficacy and safety evaluation of new liposomes still need to be further explored.

关 键 词：牙周病 牙周组织工程 脂质体 控释微球 药物传递系统 生物活性分子 组织工程支架 

分 类 号：R781.4[医药卫生—口腔医学]