SATB2在结直肠腺癌肝转移中的表达及其诊断价值  

Expression of SATB2 in liver metastasis from colorectal adenocarcinoma and its diagnosis value

作　　者：杨奇 陆荣柱[1] 吴婷 陈淼 YANG Qi;LU Rong-zhu;WU Ting;CHEN Miao(School of Medicine,Jiangsu University,Zhenjiang Jiangsu 212013;Department of Pathology,Zhenjiang Hospital of Chinese Traditional and Western Medicine,Zhenjiang Jiangsu 212002;Department of Pathology,First People′s Hospital of Zhenjiang,Zhenjiang Jiangsu 212002,China)

机构地区：[1]江苏大学医学院,江苏镇江212013 [2]镇江市中西医结合医院病理科,江苏镇江212002 [3]镇江市第一人民医院病理科,江苏镇江212002

出　　处：《江苏大学学报（医学版）》2019年第5期410-413,424,共5页Journal of Jiangsu University：Medicine Edition

基　　金：国家自然科学基金资助项目(81273124)

摘　　要：目的:探讨富含AT序列特异性结合蛋白2(special AT-rich sequence-binding protein 2,SATB2)在结直肠腺癌中的表达及其联合检测细胞角蛋白20(cytokeratin 20,CK20)、同源异型框转录因子-2(caudal-related homeodomain transcription 2,CDX2)在结直肠腺癌肝转移中的诊断价值。方法:应用免疫组织化学法检测100例结直肠腺癌及234例其他类型腺癌中SATB2的表达,同时检测179例肝内5种不同类型腺癌组织中SATB2、CK20及CDX2的表达。分析SATB2、CK20和CDX2灵敏度、特异度及准确度。结果:结直肠腺癌中SATB2阳性表达率(89%)明显高于其他类型腺癌阳性表达率(1.28%,χ2=270.107,P<0.001)。肝癌组织中来源于结直肠腺癌转移者SATB2阳性表达率为84%,非结直肠腺癌转移者SATB2阳性率仅为2.33%。表达的灵敏度、特异度及准确度:SATB2为84.00%、97.67%、93.85%;CK20为76.00%、77.52%、77.09%;CDX2为98.00%、67.44%、75.98%。结论:SATB2在结直肠腺癌中阳性表达率高,其联合CK20、CDX2检测可鉴别诊断结直肠腺癌肝转移。Objective:To investigate the diagnostic and differential value of special AT-rich sequence-binding protein 2(SATB2)in colorectal adenocarcinoma and combined detection of SATB2 with cytokeratin20(CK20)and caudal-related homeodomain transcription 2(CDX2)in hepatic metastasis of colorectal adenocarcinoma.Methods:Immunohistochemical staining was used to detect the expression of SATB2 in 100 cases of colorectal adenocarcinoma and 234 cases of other types of adenocarcinoma;and the expression of SATB2,CK20 and CDX2 in 5 different types of 179 cases adenocarcinoma tissues was detected.The sensitivity,specificity and accuracy of SATB2,CK20 and CDX2 were analyzed,respectively.Results:The positive expression rate of SATB2 in colorectal adenocarcinoma(89%)was significantly higher than that in other types of adenocarcinoma(1.28%,χ2=270.107,P<0.001).The positive expression rate of SATB2 in liver cancer tissues derived from colorectal adenocarcinoma metastasis was 84.00%,while only 2.33%in patients with non-colorectal adenocarcinoma metastasis.The expression sensitivity,specificity and accuracy were as follows:SATB2 was 84.00%,97.67%and 93.85%;CK20 was 76.00%,77.52%and 77.09%;CDX2 was 98.00%,67.44%and 75.98%.Conclusion:The positive expression rate of SATB2 in colorectal adenocarcinoma was high.Its combination with CK20 and CDX2 could be used to differentiate and diagnose liver metastasis of colorectal adenocarcinoma.

关 键 词：富含AT序列特异性结合蛋白2 细胞角蛋白20 同源异型框转录因子-2 结直肠腺癌 肝转移 

分 类 号：R735.35[医药卫生—肿瘤]