小鼠痤疮模型研究进展  

Progress in the use of mouse models of acne

作　　者：陈尔净 刘晓伟 卢丹 黄敏敏 叶陈庚 黄学嵘 陈永欣 周艳平 CHEN Erjing;LIU Xiaowei;LU Dan;HUANG Minmin;YE Chengeng;HUANG Xuerong;CHENYongxin;ZHOU Yanping(Science New School of Medicine,Guangxi University of Traditional ChineseMedicine,Nanning,530200,China;Department of Physiology,Basic Medical College,Guangxi University of Traditional Chinese Medicine,Nanning 530200)

机构地区：[1]广西中医药大学赛恩斯新医药学院,南宁530200 [2]广西中医药大学基础医学院生理学教研室,南宁530200

出　　处：《中国比较医学杂志》2019年第10期117-121,共5页Chinese Journal of Comparative Medicine

基　　金：广西中医药大学2018年广西一流学科建设项目重点课题项目(2018XK021);广西中医药大学校级科研项目青年基金项目(2017QN007);2018年自治区级大学生创新创业训练计划立项项目(201813643028)

摘　　要：根据不同的实验目的选择合适的小鼠痤疮模型对于研究痤疮的发病机制或评估抗痤药物的疗效具有重要意义。依据造模的原理将小鼠痤疮模型归纳为丙酸杆菌、化学物质刺激、雄激素三类。以小鼠痤疮模型分类为切入点,对其建模方法、适用范围及优缺点进行综述,以利于在痤疮的研究中选择适合的小鼠痤疮模型。The choice of an appropriate mouse model of acne according to the experimental purpose is very important for the study of the pathogenesis of acne or the evaluation of the efficacy of anti-acne drugs. According to the principle of modeling, mouse models of acne were classified into three categories: Propionibacterium acne, chemical acne, and androgen-induced acne. Taking the classification of mouse acne models as its starting point, this paper summarizes the modeling method, the scope of their applications, and their advantages and disadvantages, to facilitate the selection of a suitable mouse model for acne research.

关 键 词：痤疮 小鼠 动物模型 

分 类 号：R-33[医药卫生]