技术因素对局部晚期非小细胞肺癌放疗剂量的影响  

The Effect of Technical Factors on Radiotherapy Dose of Local Advanced Non-small Cell Lung Cancer

作　　者：李文辉[1] 王丽[1] 柏晗[1] 夏耀雄[1] 李云芬[1] 赵毅[1] LI Wen-hui;WANG Li;BAI Han(Department of Radiation Oncology,The Third Affiliated Hospital of Kunming Medical University/Yunnan Provincial Cancer Hospital,Kunming 650118,China)

机构地区：[1]昆明医科大学第三附属医院(云南省肿瘤医院)放射治疗中心

出　　处：《医学与哲学》2019年第19期77-80,F0003,共5页Medicine and Philosophy

基　　金：2016年国家自然科学基金项目(81660504);2017年云南省卫生内设研究机构项目(2017NS191);2018年云南省卫生内设研究机构项目(2018NS0065)

摘　　要：从RTOG0617试验结果出发,探讨技术因素对局部晚期非小细胞肺癌放疗剂量的影响。RTOG0617试验得出“60Gy的标准剂量”,但忽略了临床实践中肿瘤本身、化疗与靶向、免疫治疗等多种因素;同时放射治疗的新技术、靶区及危及器官勾画、照射体积、质量控制与保障、技术与经验、放疗计划评价工具应用与缺陷等都会影响到放射治疗剂量的确定。因此,放射治疗科医生不能只关注局部评价,要兼顾全身总剂量和全身耐受性问题。好的放疗科医生,一定是要追求非常精细、兼顾各个器官与要素平衡的计划。Based on the RTOG0617 clinical trail, this paper aims to investigate the effect of technical factors on radiotherapy dose of locally advanced non-small cell lung cancer. RTOG0617 obtained a "standard dose of 60Gy", but ignored many factors such as tumor itself, chemotherapy and targeting, and immunotherapy in clinical practice. At the same time, new technologies for radiation therapy, target areas and organ mapping, irradiation volume, quality control and protection, technology and experience, application and defects of radiation program evaluation tools will all affect the determination of radiation treatment dose. Therefore, radiotherapy doctors can not only focus on local evaluation, but also take into account the total systemic dose and systemic tolerance. A good doctor must pursue a very elaborate plan that takes into account the balance of various organs and elements.

关 键 词：非小细胞肺癌 放射治疗 放疗技术 RTOG0617试验 

分 类 号：R-02[医药卫生]