新型川芎嗪衍生物的合成  

Synthesis of Novel Ligustrazine Derivatives

作　　者：刘万冬 杨雨 李家明 黄元政 高粟繁 LIU Wan-dong;YANG Yu;LI Jia-ming;HUANG Yuan-zheng;GAO Su-fan(College of Pharmacy,Anhui University of Chinese Medicine,Hefei 230038,China;Department of Medicinal Chemestry,Anhui Academy of Chinese Medicine,Hefei 230038,China)

机构地区：[1]安徽中医药大学药学院,安徽合肥230038 [2]安徽省中医药科学院药物化学研究所,安徽合肥230038

出　　处：《合成化学》2019年第10期807-811,共5页Chinese Journal of Synthetic Chemistry

基　　金：安徽省高校自然科学研究重点项目(KJ2016A414)

摘　　要：以川芎嗪为原料,经氧化、Boekelheide重排、水解和氧化反应合成了中间体3,5,6-三甲基吡嗪-2-甲醛(4);4与取代N-4-哌啶酮发生缩合反应合成了9个新型的川芎嗪衍生物,其结构经1HNMR,13CNMR和MS(ESI)表征。3,5,6-Trimethylpyrazine-2-carbaldehyde( 4 ) was synthesized by oxidation reaction,Boekelheide rearrangement reaction,hydrolysis reaction and oxidation reaction from ligustrazine. Nine ligustrazine derivatives were synthesized by condensation reaction of 4 with substituted N -4-piperidones. The structures were characterized by 1 H NMR, 13 C NMR and MS(ESI).

关 键 词：川芎嗪 3 5 6-三甲基吡嗪-2-甲醛 哌啶酮 缩合反应 合成 

分 类 号：O626.4[理学—有机化学]