未来时间洞察与情绪状态的关系探讨：基于癌症患者的调查与脑成像研究  

Relationship between future time perspective and emotional state: A study based on the investigation and brain imaging results of cancer patients

作　　者：周佳 郑涌 陆笑非 官平 曾敏 冯攀 ZHOU Jia;ZHENG Yong;LU Xiaofei;GUAN Ping;ZENG Min;FENG Pan(School of Humanities and Management Science, Southwest Medical University, Luzhou 646000, SichuanProvince, China;Sichuan Hospital Management and Development Research Center;Facultyof Psychology, Southwest University;Department of Radiology, the Affiliated Hospital of Southwest Medical University;Department of Oncology, the Affiliated Hospital of Southwest Medical University)

机构地区：[1]西南医科大学人文与管理学院,四川泸州646000 [2]四川医院管理和发展研究中心 [3]西南大学心理学部 [4]西南医科大学附属医院放射科 [5]西南医科大学附属医院肿瘤科

出　　处：《西南医科大学学报》2019年第5期393-400,共8页Journal of Southwest Medical University

基　　金：教育部人文社会科学重点研究基地重大项目(15JJDZONGHE022)

摘　　要：目的:分析癌症患者未来时间洞察(future time perspective,FTP)、正负性情绪、典型疾病相关个体差异以及腹内侧前额叶皮层(vmPFC)脑区功能之间的关系,并探讨FTP在典型疾病相关个体差异变量和正负性情绪间的中介作用,以及高FTP组与低FTP组在vmPFC脑区的神经功能差异。方法:对422名癌症患者采用个体差异调查表、FTP量表及正负性情绪量表进行调查,采用菲利普3.0T MRI扫描仪收集功能成像数据。采用结构方程模型探讨各变量之间的关系,Bootstrap方法检验中介效应,DPARSF 4.2和REST软件对脑成像数据进行分析。结果:①FTP得分在不同的年龄阶段、受教育水平、月均收入、主观健康评价、宗教信仰、手术次数上都存在显著的统计学差异。②FTP与年龄、负性情绪呈正相关;与文化程度、月均收入、手术次数、宗教信仰、主观健康、正性情绪呈负相关。③以个体差异为预测变量,FTP为中介变量,正负情绪为结果变量构建的结构方程模型适配度良好。④神经影像学结果显示,低FTP组vmPFC的自发脑活动比高FTP组更强。⑤FTP不能直接预测vmPFC的活动变化,但是正负性情绪能够直接预测vmPFC的活动变化。结论:癌症患者的情绪状态受到多个典型疾病相关个体差异变量和FTP的影响,FTP可以中介典型疾病相关个体差异变量与正负性情绪的关系,低FTP组的vmPFC的活动水平强于高FTP组,正负性情绪可以预测vmPFC的活动状态。Objective: To analyze the relationship of future time perspective (FTP), positive and negative emotions, and typical disease-related individual differences in cancer patients with the function of the ventromedial prefrontal cortex (vmPFC) brain region, and to investigate the mediating effects of FTP between typical disease-related individual difference variables and positive and negative emotions as well as the neurological functional differences in vmPFC brain region between high FTP group and low FTP group. Methods: A total of 422 cancer patients were investigated using Individual Differences Questionnaire, FTP scale, and Positive and Negative Emotions Scale. A Philips 3.0 T MRI scanner was used to collect functional imaging data. Structural equation modeling was used to explore the relationship between the variables;the bootstrap method was used to test the mediating effects;the brain imaging data were analyzed by DPARSF 4.2 and REST software. Results: There were significant diffferences in FTP score between different age groups, education levels, mean monthly incomes, subjective health assessments, religious beliefs, and operation times. FTP was positively correlated with age and negative emotion, while negatively correlated with education level, mean monthly income, operation time, religious belief, subjective health assessment, and positive emotion. The structural equation modeling fitted well, with individual differences as predictive variables, FTP as mediating variable, and positive and negative emotions as result variables. Neuroimaging results revealed that spontaneous brain activity in the vmPFC was stronger in the low FTP group than in the high FTP group. Changes in the activity of vmPFC could not be directly predicted by FTP, but could be directly predicted by positive and negative emotions. Conclusion: The emotional state of cancer patients is influenced by multiple typical disease-related individual difference variables and FTP. FTP can mediate the relationship between typical disease-related indi

关 键 词：未来时间洞察 正负性情绪 个体差异 腹内侧前额叶皮层 

分 类 号：R73[医药卫生—肿瘤] G44[医药卫生—临床医学]