盐酸右美托咪定人体药动学研究进展  

Progress in Human Pharmacokinetics of Dexmedetomidine Hydrochloride

作　　者：贾冰 孙树茂[2] JIA Bing;SUN Shu-mao(The Third People's Hospital of Datong, Datong Shanxi, 037000;School of Medicine, Shanxi Datong University, Datong Shanxi, 037009)

机构地区：[1]大同市第三人民医院,山西大同037000 [2]山西大同大学医学院,山西大同037009

出　　处：《山西大同大学学报（自然科学版）》2019年第5期49-51,共3页Journal of Shanxi Datong University(Natural Science Edition)

摘　　要：临床应用右美托咪定时,往往凭经验来调整剂量。由于患者个体差异大,剂量难以精确控制,因此有必要对其用药后的实际血浆药物浓度进行监测,并作为调整药物剂量的依据。有关右美托咪定的人体药动学研究已有报道,大多采用液相色谱串联质谱法进行检测。该法将液相色谱的高效分离能力和串联质谱的高度灵敏性有机结合起来,大大提高了检测效率和灵敏度,但报道的结果差异很大。另外,国内对特殊疾病或特殊群体患者的右美托咪定人体药动学研究甚少。因此,研究右美托咪定在特殊群体或特殊疾病患者的药动学具有重要的临床应用价值。The dose of Dexmedetomidine (DEX) is always adjusted empirically in clinical application. Due to the large individual differences of patients, it is difficult to accurately control the dose, so it is necessary to monitor the actual plasma drug concentration of DEX after administration, serving as the basis for adjusting the drug dose. Human pharmacokinetic studies of DEX have been reported, most of which were detected by liquid chromatography tandem mass spectrometry. This method organically combines the high separation capacity of liquid chromatography and the high sensitivity of tandem mass spectrometry, greatly improving the efficiency and sensitivity of detection, but with large differences. In addition, there have been few studies on the pharmacokinetics of DEX in patients with special diseases or of special groups in China. Therefore, pharmacokinetic studies on DEX in special populations or patients with special diseases have important clinical application values.

关 键 词：右美托咪定 药动学 液相色谱 质谱 

分 类 号：R917[医药卫生—药物分析学]