下颌骨牵引成骨术对Pierre-Robin序列征患儿健康生存质量的影响  

Effect of mandibular distraction osteogenesis on quality of life in children with Pierre-Robin sequence

作　　者：涂晶晶 沈卫民[1] 马蕾[1] 孔亮亮 眭婕[1] 郑欣 Tu Jingjing;Shen Weimin;Ma Lei;Kong Liangliang;Sui Jie;Zheng Xin(Department of Plastic Surgery, Children′s Hospital of Nanjing Medical University, Nanjing 210000, China)

机构地区：[1]南京医科大学附属儿童医院烧伤整形科,210000

出　　处：《中华整形外科杂志》2019年第9期913-916,共4页Chinese Journal of Plastic Surgery

基　　金：南京医科大学科技发展基金-面上项目(2016NJMU095).

摘　　要：目的探讨Pierre-Robin序列征(Pierre-Robin Sequence,PRS)患儿行下颌骨牵引成骨术(mandibular distraction osteogenesis,MDO)对健康生存质量的影响.方法选取自2017年1月至8月在南京医科大学附属儿童医院诊疗的44例PRS患儿,男24例,女20例,年龄7 d至16个月.用中文版格拉斯格儿童受益量表(Glasgow children′s benefit inventory,GCBI)调研其术后在生理、情感、学习、活力4个维度的健康生存质量,收集入组患儿临床资料及生活质量评分,非参数检验的两独立样本Mann-Whitney U检验进行对比分析.结果本组44例接受MDO手术的PRS患儿,GCBI总分为46分,表示总体生活质量均得到积极改善;生理维度得分为72分,得分最高,表现出最为积极的变化.不同程度PRS患儿的GCBI总评分,Ⅰ型为62分,Ⅱ型为43分,Ⅲ型为18分.非参数检验显示,Ⅰ型的生活质量改善高于Ⅲ型,二者差异有统计学意义(Z=-3.34,P=0.01).Ⅰ型和Ⅱ型、Ⅱ型和Ⅲ型间比较,差异无统计学意义(P>0.05).结论 MDO对PRS患儿健康生存质量的改善有着积极的影响,生理方面改善最明显,严重程度越轻的患儿术后生活质量改善越显著.Objective To explore the impact role of Mandibular Distraction Osteogenesis technique ( MDO) on the health quality of life in children with Pierre-Robin Sequence ( PRS). Methods From January 2017 to August 2017, 44 cases of children with PRS admitted in children's hospital of Nanjing Medical University were recruited. Glasgow Children's benefit inventory(GCBI), Chinese version was used to study postoperative qualify of life in four aspects:physiology, emotions, learning, and vitality. Clinical data and the quality of life score were collected from the patients, and comparison analysis was performed. Results GCBI total score of the 44 cases of PRS treated with MDO surgery was 46, indicating that the overall quality of life was improved;Physical dimension score was 72, which was the highest, showing the most positive changes. GCBI total scores for the children with different types of PRS were typeⅠ62, type Ⅱ43, type Ⅲ18, respectively. Nonparametric test showed that quality of life in typeⅠpatients was improved compared to typeⅢ. The difference was statistically significant (Z =-3. 34, P=0. 01).For the comparisons between type Ⅰ and Ⅱ and type Ⅱ and type Ⅲ, there was no statistically significant difference ( P>0. 05). Conclusions MDO plays a positive role in improving life of quality . Physiological conditions were the aspects that were improved most. The milder the case is, the more the postoperative quality of life is improved.

关 键 词：PIERRE ROBIN序列征 下颌骨 骨生成 牵张 生活质量 

分 类 号：R782.2[医药卫生—口腔医学]