前列腺癌组织中Kindlin-2和Clusterin蛋白表达及与PSA含量的相关性  

The correlation between PSA and expression of Kindlin-2 and Clusterin in prostate cancer tissue

作　　者：王超奇[1] 金秀琴[1] 乌云毕力格 吉日嘎拉[1] 张楠栋 Wang Chaoqi;Jin Xiuqin;Wuyunbilige;Jirigala;Zhang Nandong(Department of Urinary Surgery,Inner Mongolia Nationalities University Affiliated Hospital,Inner Mongolia Tongliao 028007,China.)

机构地区：[1]内蒙古民族大学附属医院泌尿外科

出　　处：《现代肿瘤医学》2019年第21期3843-3845,共3页Journal of Modern Oncology

基　　金：内蒙古民族大学科技基金项目(编号:NMDGY1438,NMDY18080);内蒙古民族大学附属医院博士科研启动基金(编号:2017BSQD02)

摘　　要：目的:探讨前列腺特异性抗原(PSA)含量和前列腺癌(PCA)组织中Clusterin、Kindlin-2蛋白阳性表达的相关性,研究前列腺癌的治疗策略。方法:45例前列腺增生和55例前列腺癌组织应用免疫组织化学方法检测凋亡蛋白Kindlin-2、Clusterin的表达并检测对应病例的血浆PSA含量。结果:Clusterin、Kindlin-2蛋白在前列腺癌组织中的阳性表达率分别为50.9%(28/55)、63.6%(35/55),Clusterin和Kindlin-2蛋白在前列腺增生组织中的阳性表达率分别为0(0/45)、51.1%(23/45)。在前列腺癌和前列腺增生组织中Clusterin和Kindlin-2阳性表达率具有统计学差异(P<0.05);Clusterin和Kindlin-2蛋白表达与前列腺癌病理分级、临床分期、转移情况和PSA含量相关,差异有统计学意义(P<0.05)。结论:联合检测Kindlin-2、Clusterin蛋白和PSA可为前列腺癌提供一种新的联合检查方法。Objective:To detect the expression of Kindlin-2,Clusterin and PSA and their correlation in prostate cancer(PCA),we investigated the methods of therapy to PCA.Methods:Immunohistochemistry was employed to measure the expression of Kindlin-2 and Clusterin in 55 cases of prostatic cancer and 45 cases of benign prostatic hyperplasia and PSA in prostate.Results:In prostatic cancer tissue,the positive expression rates of Clusterin and Kindlin-2 were 50.9%(28/55),63.6%(35/55).In benign prostatic hyperplasia tissue,the positive expression rates of Kindlin-2 and Clusterin were 0(0/45),51.1%(23/45).The positive expression of Kindlin-2 and Clusterin between prostatic cancer and benign prostatic hyperplasia was significantly different(P<0.05).The positive expression of Kindlin-2 and Clusterin were related with the histologic grade,clinical stage,metastasis and PSA(P<0.05).Conclusion:The joint detection of Kindlin-2,Clusterin and PSA may offer a new method of joint inspection for prostate cancer.

关 键 词：前列腺癌 Kindlin-2 CLUSTERIN 前列腺特异性抗原 

分 类 号：R737.25[医药卫生—肿瘤]