局部亚低温联合呋塞米治疗急性大面积脑梗死疗效观察  

Therapeutic effect of local mild hypothermia combined with furosemide on acute massive cerebral infarction

作　　者：戴崇亮 胡琳琳 李立[1] 牛庆东[1] DAI Chong-liang;HU Lin-lin;LI Li;NIU Qing-dong(Department of Neurology,Xi'an Aerospace General Hospital,Xi'an,Shaanxi 710100;Xi'an Aerospace General Hospital,Xi'an 710100,Shaanxi,CHINA)

机构地区：[1]西安航天总医院神经内科,陕西西安710100 [2]西安航天总医院检验科,陕西西安710100

出　　处：《海南医学》2019年第20期2622-2625,共4页Hainan Medical Journal

摘　　要：目的观察局部亚低温联合呋塞米治疗急性大面积脑梗死的临床疗效及对患者脑保护作用。方法将西安航天总医院2018年1月至2019年1月收治的90例急性大面积脑梗死患者按随机数表法分为对照组和观察组,每组45例。对照组给予呋塞米治疗,观察组给予局部亚低温联合呋塞米治疗。比较两组患者的临床治疗效果、治疗前及治疗后14d美国国立卫生院脑卒中量表(NIHSS)神经功能评分和Bathel指数(BI)评分,以及血清超氧化歧化酶(SOD)、一氧化氮(NO)、神经元特异性稀醇化酶(NSE)水平。结果观察组患者的临床治疗总有效率为86.67%,明显高于对照组的62.22%,差异具有统计学意义(P<0.05);观察组患者治疗后的NIHSS神经功能评分为(9.84±1.75)分,明显低于对照组的(12.69±2.03)分,BI评分为(51.30±9.26)分,明显高于对照组的(43.28±7.49)分,差异均具有统计学意义(P<0.05);观察组患者治疗后的血清SOD水平为(104.86±13.12)NU/mL,明显高于对照组的(95.77±12.68)NU/mL,血清NO和NSE水平分别为(59.14±8.33)μmol/L、(6.39±0.97)ng/mL,均明显低于对照组的(71.25±9.74)μmol/L、(10.58±2.03)ng/mL,差异均具有统计学意义(P<0.05)。结论局部亚低温联合呋塞米治疗急性大面积脑梗死,疗效确切,同时能明显发挥脑保护作用。Objective To observe the clinical efficacy of local mild hypothermia combined with furosemide in the treatment of acute massive cerebral infarction and its protective effect on patients' brain. Methods A total of 90 patients with acute massive cerebral infarction admitted to Xi'an Aerospace General Hospital from January 2018 to January 2019 were randomly divided into control group and observation group according to the random number table method, with 45 patients in each group. The control group was treated with furosemide, and the observation group was treated with local mild hypothermia combined with furosemide. The clinical efficacy of the two groups was compared, as well as the neurological function scores performed by the National Institutes of Health Stroke Scale (NIHSS) and the Bathel index (BI) scores before and 14 days after treatment, and the serum levels of superoxide dismutase (SOD), nitric oxide (NO) and neuron specific enolase (NSE). Results The total effective rate of clinical treatment was 86.67% in the observation group, which was significantly higher than 62.22% in the control group, and the difference was statistically significant (P<0.05). After treatment, the NIHSS neurological function score was 9.84±1.75 in the observation group, which was significantly lower than 12.69±2.03 in the control group;and the BI score was 51.03±9.26 in the observation group, significantly higher than 43.28±7.49 in the control group;both differences were statistically significant (P< 0.05). After treatment, the serum levels of SOD was (104.86±13.12) NU/mL in the observation group, which was significantly higher than (95.77±12.68) NU/mL in the control group;and the serum levels of NO and NSE were (59.14± 8.33)μmol/L and (6.39±0.97) ng/mL in the observation group, respectively, which were significantly lower than corresponding (71.25±9.74)μmol/L and (10.58±2.03) ng/mL in the control group;all differences were statistically significant (P<0.05). Conclusion Local mild hypothermia combined with furosemide i

关 键 词：亚低温 呋塞米 急性大面积脑梗死 脑保护 临床疗效 

分 类 号：R743.33[医药卫生—神经病学与精神病学]