帕金森病合并体位性低血压患者自主神经功能情况及相关性研究  

Autonomic dysfuction and its correlation research in patients with Parkinson’s disease combined with orthostatic hypotension

作　　者：麻红梅[1] 麻守花 MA Hong-mei;MA Shou-hua(Department of Neurology, Qinghai Provincial People’s Hospital,Xining 810000, China)

机构地区：[1]青海省人民医院神经内科,西宁810000 [2]青海省互助土族自治县人民医院眼科

出　　处：《临床神经病学杂志》2019年第5期337-340,共4页Journal of Clinical Neurology

摘　　要：目的探讨帕金森病(PD)合并体位性低血压(OH)患者的自主神经功能。方法选取PD患者76例,经卧立位血压测量后分为PD-OH组(n=40)和非OH组(n=36),对该两组患者进行自主神经症状量表(SCOPA-AUT)评估。结果两组间年龄、病程及Hoehn-Yahr分期的差异有统计学意义(均P<0.05)。PD-OH组SCOPA-AUT总分明显高于非OH组(P<0.05);PD-OH组SCOPA-AUT量表6个系统评估中消化系统、泌尿系统、心血管系统、交感/副交感系统、性功能系统的评分均明显高于非OH组(均P<0.05)。结论 PD合并OH患者的自主神经功能障碍较非OH患者严重,临床应加强对PD合并OH患者的诊断及管理。Objective To investigate the autonomic dysfunction in patients with Parkinson’s disease(PD) combined with orthostatic hypotension(OH). Methods Seventy-six PD patients were selected and divided into PD-OH group(n=40) and non-OH group(n=36) after the measurement of blood pressure in the supine to standing position. The scales for outcomes in PD-autonomic test(SCOPA-AUT) was used to evaluate the patients in the two groups. Results There were significant differences in age, duration and Hoehn-Yahr stage between the two groups(all P<0.05). The total value of SCOPA-AUT in the PD-OH group was significantly higher than that in the non-OH group(P<0.05). The scores of digestive system, urinary system, cardiovascular system, sympathetic/parasympathetic system and sexual function of SCOPA-AUT in the PD-OH group were all significantly higher than those in the non-OH group(all P<0.05). Conclusion The autonomic dysfunction of PD patients with OH is more serious than that of PD patients without OH, and clinical diagnosis and management of PD patients with OH should be strengthened.

关 键 词：帕金森病合并体位性低血压 自主神经症状量表 临床研究 

分 类 号：R742.5[医药卫生—神经病学与精神病学]