CSF外泌体在CNS疾病诊断与应用价值的研究进展  

Research progress on diagnosis and application value of CSF exosome in CNS disease

作　　者：葛小旭 季秋虹[1] GE Xiao-xu;JI Qiu-hong(Department of Neurology, Affiliated Hospital of Nantong University,Nantong 226001,China)

机构地区：[1]南通大学附属医院神经内科

出　　处：《临床神经病学杂志》2019年第5期383-386,共4页Journal of Clinical Neurology

基　　金：国家自然科学基金(81201016);江苏省“六大人才高峰”高层次人才培养资助项目(WSN-094);南通市民生示范推广项目(MS32015026)

摘　　要：外泌体是由细胞内多囊泡体与细胞膜融合释放到胞外的囊泡。外泌体由多种细胞分泌,存在于多种体液中。外泌体中含有蛋白质、脂质和核酸,可参与细胞间的信息交流。CNS细胞分泌的外泌体参与了CNS疾病发生发展过程。研究表明,外泌体不仅可以作为CNS疾病的早期诊断标志物,对CNS疾病也具有治疗潜能。本文着重阐述了CSF中外泌体在CNS疾病发生发展及诊治中的研究进展。Exosomes are vesicles released into extracellular cells by fusion of intracellular polyvesicles and cell membranes. Exosomes are secreted by a variety of cells and exist in a variety of body fluids. Exosomes contain proteins, lipids and nucleic acids, which can participate in the information exchange between cells. Exosomes secreted by CNS cells are involved in the occurrence and development of CNS diseases. Recent studies have shown that exosomes can not only serve as early diagnostic markers for CNS diseases, but also have therapeutic potential for CNS diseases. In this paper, the development, diagnosis and treatment of CSF exosomes in CNS diseases were reviewed.

关 键 词：外泌体 CNS疾病 诊断标志物 发病机制 

分 类 号：R741[医药卫生—神经病学与精神病学]