左乙拉西坦单药治疗儿童癫痫的疗效及其对认知功能影响的临床观察  

Clinical observation of levetiracetam in the treatment of epilepsy in children and its effect on cognitive function

作　　者：刘开宇[1] 王建怡[1] 杨再兰 李家琼 邱钟燕[1] Liu Kaiyu;Wang Jianyi;Yang Zailan;Li Jiaqiong;Qiu Zhongyan(Department of Pediatrics,Guizhou Provincial People' s Hospital,Guiyang,Guizhou,550001,China)

机构地区：[1]贵州省人民医院儿科

出　　处：《当代医学》2019年第31期82-84,共3页Contemporary Medicine

摘　　要：目的观察左乙拉西坦(LEV)单药治疗儿童癫痫的疗效及其对认知功能的影响。方法选择2016年9月至2018年8月本院收治的116例癫痫患儿作为研究对象,并随机分为对照组和治疗组,各58例。对照组单用丙戊酸钠治疗,治疗组单用LEV治疗,两组均给予6个月治疗。采用丹佛发育筛查测试(DST)检测患儿认知功能。比较两组疗效及治疗前后认知功能,观察不良反应发生情况。结果治疗组患儿治疗总有效率(89.65%)略高于对照组(87.93%),两组疗效比较差异无统计学意义。治疗前,两组患儿的认知功能比较差异无统计学意义;治疗后,两组患儿DQ分布比例均略有改善,但两组认知功能比较差异无统计学意义。治疗组患儿不良反应总发生率(5.16%)明显低于对照组(17.24%),两组比较差异具有统计学意义(P<0.05)。结论LEV单药治疗儿童癫痫的有效率高,对认知功能影响小,不良反应少。Objective To observe the effect of levetiracetam (LEV) on epilepsy in children and its influence on cognitive function.Methods 116 children with epilepsy from September 2016 to August 2018 in our hospital were selected as subjects and randomly divided into control group and treatment group,with 58 cases in each group.The control group was treated with sodium valproate alone,the treatment group was treated with LEV alone,and both groups were given 6 months of treatment.Denver Development Screening Test (DST) was used to test the cognitive function of children. The efficacy of the two groups and cognitive function before and after treatment were compared,and the occurrence of adverse reactions was observed.Results The total effective rate of treatment group (89.65%) was slightly higher than that of control group (87.93%).There was no significant difference between the two groups.Before treatment,there was no significant difference in cognitive function between the two groups.After treatment,the proportion of DQ distribution in the two groups was slightly improved,but there was no significant difference in cognitive function be tween the two groups.The total incidence of adverse reactions in children in the treatment group (5.16%) was significantly lower than that in the control group (17.24%),and the difference between the two groups was significant (P<0.05).Conclusion LEV single drug treatment of epilepsy in children has high efficiency,little impact on cognitive function and less adverse reactions.

关 键 词：左乙拉西坦 癫痫 儿童 认知功能 不良反应 

分 类 号：R742.1[医药卫生—神经病学与精神病学]