吲哚菁绿荧光显像技术在结直肠癌手术中的应用  

Application of indocyanine green fluorescence imaging in colorectal cancer surgery

作　　者：曹键[1] 申占龙[1] 叶颖江[1] 王杉[1] Cao Jian;Shen Zhanlong;Ye Yingjiang;Wang Shan(Department of Gastrointestinal Surgery, Peking University People′s Hospital, Beijing 100044, China)

机构地区：[1]北京大学人民医院胃肠外科,100044

出　　处：《中华胃肠外科杂志》2019年第10期997-1000,共4页Chinese Journal of Gastrointestinal Surgery

基　　金：国家自然科学基金(81702354).

摘　　要：吲哚菁绿(ICG)荧光显像技术在外科手术中的应用十分广泛。越来越多的研究表明,在结直肠手术的吻合口血供评估中,术中荧光显像是一种安全可行的方法,该技术的应用有可能会降低吻合口漏的发生率。同时,ICG亦可用于标记病灶位置、辨识前哨淋巴结、保护输尿管等;甚至可在结直肠癌腹膜转移、肝转移的手术中,提供检测和指导作用。ICG荧光显像技术可提高肿瘤切除的准确性,改善预后,为结直肠外科手术带来巨大获益。同时,从现有的研究来看,ICG荧光显像技术在结直肠癌手术中的应用尚处在初级阶段,荧光显像应用的剂量、注射部位、观察时间等尚无标准及规范可循,多缺乏前瞻性的随机对照研究。因此,有必要对该项技术进行深入的研究,建立标准化的操作规范,提高肿瘤切除的安全性和准确性,改善患者预后。Indocyanine green (ICG) fluorescence imaging has been widely used in surgery. In colorectal surgery specifically, more and more studies have shown that intraoperative fluorescence imaging is a safe and feasible method to assess anastomotic perfusion, and its use may decrease the incidence of anastomotic leakage. Meanwhile, indocyanine green can also be used to mark the location of lesion, identify sentinel lymph nodes, protect the ureter, and so on. It can also provide detection and guidance in the operation of peritoneal metastasis and liver metastasis of colorectal cancer. The application of indocyanine green fluorescence imaging can offer great value for surgery through improving the accuracy and outcomes of oncological resections. According to existing studies, we are still at an early application stage of indocyanine green fluorescence imaging technology in colorectal surgery. Lacking prospective randomized controlled studies, neither standards nor guidelines for injection dosage, site and observation period are satisfactory. Therefore, deep researches and establishment of standardized operational procedure are required to enhance the safety and accuracy of tumor resection and improve outcomes.

关 键 词：结直肠肿瘤 吲哚菁绿 荧光显像 手术 

分 类 号：R735[医药卫生—肿瘤]