新型DNA电化学生物传感器用于乳腺癌转移基因的研究及应用  

Detection of Breast Cancer Marker Gene by DNA Electrochemical Biosensor

作　　者：林启凰 林聪炜 叶廷秀 张岗 陈丹 陈仲巍 Lin Qihuang;Lin Congwei;Ye Tingxiu;Zhang Gang;Chen Dan;Chen Zhongwei(Pharmacy Department of Xiamen Medical College,Xiamen,361000;No. 174th Hospital of PLA,Xiamen,361000)

机构地区：[1]厦门医学院药学系,厦门361000 [2]解放军第一七四医院,厦门361000

出　　处：《基因组学与应用生物学》2019年第9期4377-4382,共6页Genomics and Applied Biology

基　　金：福建省教育厅中青年教师教育科研项目(JAT170705);厦门医学院自然科学类项目(K2016-19; K2016-37);厦门医学院博士启动资金项目(KX1513)共同资助

摘　　要：乳腺癌是危害女性健康的最常见的恶性肿瘤,其每年发病率及死亡率不断升高,其中乳腺癌转移是乳腺癌患者致死的主要原因。新型DNA电化学生物传感器,具有灵敏度高、重现性好、易于操作、准确性好等诸多优点,能够较好地应用于临床上常规检查难以发现的乳腺癌早期转移标志基因及序列的检测,为下一步乳腺癌病人实际样品的检测奠定坚实的实验基础,从而有效降低了乳腺癌死亡率,并且改善乳腺癌患者生存。因此研究一种新型的DNA电化学生物传感器能够快速、灵敏并准确的检测出乳腺癌转移标志基因对于乳腺癌的早期诊断和治疗具有重要的意义。Breast cancer is the most common malignant tumor that affects women's health, the annual incidence and mortality are increasing, and breast cancer metastasis is the leading cause of death. DNA electrochemical biosensors with high specificity good reproducibility easy operation and good accuracy, it can be applied to early detection of breast cancer metastasis marker genes which are difficult to routinely detect, It lays a solid experimental foundation for the next step in the detection of actual samples of breast cancer patients, which can reduce breast cancer mortality and improve the survival of breast cancer patients. Therefore, it is important to study a novel DNA electrochemical biosensor that can marker genes of detect breast cancer metastasis quickly, sensitively and accurately for the early diagnosis and treatment in clinic.

关 键 词：乳腺癌 乳腺癌标志基因 DNA电化学生物传感器 

分 类 号：R737.9[医药卫生—肿瘤]