玻璃酸钠联合氯替泼诺滴眼液与单纯玻璃酸钠滴眼液治疗儿童干眼症的疗效比较  

A comparative study on the efficacy of sodium hyaluronate combined with Clotipenol eye drops and sodium hyaluronate eye drops alone in treatment of dry eyes in pediatric patients with dry eye syndrome

作　　者：邹广程[1] 叶静娟[1] 黄铃[1] ZOU Guang-cheng;YE Jing-juan;HUANG Ling(Department of Ophthalmology,The Second People's Hospital of Wuxi,Wuxi Jiangsu 214000,China)

机构地区：[1]无锡市第二人民医院眼科

出　　处：《临床和实验医学杂志》2019年第22期2444-2447,共4页Journal of Clinical and Experimental Medicine

基　　金：江苏省卫生计生委科研面上项目(MS201765)

摘　　要：目的比较玻璃酸钠联合氯替泼诺滴眼液与单纯玻璃酸钠滴眼液治疗儿童干眼症的临床疗效。方法回顾性分析2017年5月至2018年4月无锡市第二人民医院眼科收治的156例(189眼)儿童干眼症患儿的临床资料,按照治疗方法不同分为两组:观察组78例(92眼)和对照组78例(97眼)。对照组患儿采用玻璃酸钠滴眼液治疗,观察组患儿在此基础上辅以氯替泼诺滴眼液治疗,均以4周为1个疗程,连续治疗2个疗程。比较两组患儿的临床疗效、临床症状评分、干眼症状、泪膜破裂时间(BUT)、角膜荧光素染色评分(FL)、泪液分泌试验(SIT)及治疗安全性。结果观察组患儿总有效率为93.6%,高于对照组的79.5%,差异具有统计学意义(P<0.05);观察组患儿治疗后的临床症状评分、FL评分分别为(11.03±2.64)、(3.11±0.59)分,均分别低于对照组的(20.49±2.13)分、(6.24±0.93)分,差异具有统计学意义(P<0.05);观察组患儿治疗后BUT、SIT分别为(9.38±1.35)s、(2.82±0.37)mm/5 min,均分别高于对照组的(6.57±1.09)s、(2.61±0.25)mm/5 min,差异具有统计学意义(P<0.05)。两组患儿药物不良反应发生率分别为7.7%、6.4%,差异无统计学意义(P>0.05)。结论相较于单一应用玻璃酸钠滴眼液,辅以氯替泼诺滴眼液治疗儿童干眼症的治疗效果更为显著,能进一步改善干眼症状、眼表环境及泪膜稳定性,延长泪膜破裂时间,且治疗安全可靠。Objective To compare the clinical efficacy of sodium hyaluronate combined with loteprednol eye drops and sodium hyaluronate eye drops in treatment of pediatric patients with dry eye syndrome.Methods Retrospective analysis on the clinical data of 156 pediatric patients(189 eyes)with dry eye admitted to Wuxi Second People's Hospital during May 2017 to April 2018,they were divided into two groups according to different treatment methods:78 cases(92 eyes)in observation group and 78 patients(97 eyes)in control group.Pediatric patients in control group were treated with sodium hyaluronate eye drops.Pediatric patients in observation group were treated with loteprednol eye drops on the basis of treatment in control group.All these patients were treated with 4 weeks as a course for 2 courses.The clinical efficacy,clinical symptom scores,dry eye symptoms,break-up time(BUT),corneal fluorescein staining scores(FL),Schirmer I test(SIT),and safety of treatment were compared between these two groups.Results The total effective rate in observation group was 93.6%,it was higher than that of control group(P<0.05).The clinical symptom scores and FL scores of patients in observation group after treatment were(11.03±2.64)scores and(3.11±0.59)scores,respectively,which were lower than those of control group(20.49±2.13)scores and(6.24±0.93)scores,respectively(P<0.05).After treatment,BUT and SIT in observation group were(9.38±1.35)s,(2.82±0.37)mm/5 min respectively,which were higher than those of control group(6.57±1.09)s,(2.61±0.25)mm/5 min(P<0.05).The incidence rates of adverse drug reactions in these two groups were 7.7%and 6.4%,respectively,without statistical significance(P>0.05).Conclusion In comparison with single application of sodium hyaluronate eye drops,the therapeutic effect of glucocorticoid clotipenol eye drops in treatment of pediatric patients with dry eyes is more significant,it can further improve the symptoms of dry eyes,eye surface environment and tear film stability,and it can extend the tear film rupture tim

关 键 词：儿童干眼症 玻璃酸钠滴眼液 氯替泼诺滴眼液 

分 类 号：R777.34[医药卫生—眼科]