术前新辅助化疗联合经尿道等离子电切根治术治疗老年肌层浸润性膀胱癌的临床效果  

Clinical effect of preoperative neoadjuvant chemotherapy combined with transurethral plasmakinetic resection in the treatment of senile muscle-invasive bladder cancer

作　　者：成正祥 范广峰 CHENG Zheng-xiang;FAN Guang-feng(People's Hospital of Tongchuan,Tongchuan 727000,China)

机构地区：[1]铜川市人民医院

出　　处：《临床医学研究与实践》2019年第31期30-32,共3页Clinical Research and Practice

摘　　要：目的探讨术前新辅助化疗联合经尿道等离子电切根治术治疗老年肌层浸润性膀胱癌的临床效果。方法选择2014年1月至2016年1月我院收治的60例老年肌层浸润性膀胱癌患者的临床资料进行回顾性分析,根据治疗方法不同将患者分为对照组和观察组,各30例。对照组行经尿道等离子电切根治术治疗,观察组行新辅助化疗联合经尿道等离子电切根治术治疗。比较两组的肿瘤直径、近期疗效、术后并发症发生情况、远期存活率、术后局部复发率和生活质量评分。结果观察组化疗后最大、最小肿瘤直径显著小于化疗前及对照组(P<0.05)。术后2个月,观察组客观缓解率、疾病控制率分别为46.67%、80.00%,均高于对照组的20.00%、50.00%(P<0.05)。两组术后并发症总发生率比较,差异无统计学意义(P>0.05)。观察组术后1、2、3年的存活率均高于对照组,术后局部复发率均低于对照组(P<0.05)。术后随访1、2、3年时,观察组存活患者的生活质量各项评分均高于对照组(P<0.05)。结论术前新辅助化疗联合经尿道等离子电切根治术可提高老年肌层浸润性膀胱癌患者的近期疗效,其术后并发症少,安全性良好,还可减少患者术后局部复发,提高远期存活率,有利于改善患者生活质量。Objective To investigate the clinical effect of preoperative neoadjuvant chemotherapy combined with transurethral plasmakinetic resection in the treatment of senile muscle-invasive bladder cancer. Methods From January 2014 to January 2016, the clinical data of 60 patients with senile muscle-invasive bladder cancer admitted in our hospital were retrospectively analyzed. According to the different treatment methods, the patients were divided into control group and observation group, with 30 cases in each group. The control group was treated by transurethral plasmakinetic resection, and the observation group was treated by neoadjuvant chemotherapy combined with transurethral plasmakinetic resection. The tumor diameter, short-term efficacy, postoperative complications, long-term survival rates, postoperative local recurrence rates and scores of quality of life were compared between the two groups. Results The diameter of the largest and smallest tumor in the observation group after chemotherapy were significantly smaller than those before chemotherapy and in the control group (P<0.05). At 2 months after operation, the objective remission rate and disease control rate of the observation group were 46.67% and 80.00% respectively, which were higher than 20.00% and 50.00% of the control group (P<0.05). There was no significant difference in the total incidences of postoperative complications between the two groups (P>0.05). The survival rates of postoperative 1, 2, 3 years in the observation group were higher than those in the control group, and the postoperative local recurrence rates were lower than those in the control group (P<0.05). After 1, 2 and 3 years of postoperative follow-up, the scores of quality of life of survival patients in the observation group were higher than those in the control group (P<0.05). Conclusion Preoperative neoadjuvant chemotherapy combined with transurethral plasmakinetic resection can improve the short-term efficacy of senile muscle-invasive bladder cancer, with fewer complications and g

关 键 词：老年肌层浸润性膀胱癌 新辅助化疗 经尿道等离子电切根治术 生活质量 

分 类 号：R737.14[医药卫生—肿瘤]