C-erbB-2基因蛋白在三种癌瘤组织中表达的分析  

Study on expression C-erbB-2 Gene in Three Different types

作　　者：薄爱华[1] 王金科[1] 李洪涛[1] 杨晓明[2] 白丽娜 

机构地区：[1]张家口医学院电镜室,075000 [2]石家庄白求恩军医学院,050000 [3]张家口沈家屯医院,075000

出　　处：《张家口医学院学报》2002年第5期1-3,共3页

摘　　要：目的 :为探讨C -erbB - 2蛋白在胃癌、大肠癌和乳腺癌中表达的异同和意义。方法 :取胃癌 114例、大肠癌 10 4例和乳腺癌 10 6例 ,石蜡切片 ,SP免疫组织化学染色。结果 :C-erbB - 2在胃癌、大肠癌和乳腺癌中的阳性率分别为 71.9%、5 7.7%和 5 4 .7%。C -erbB - 2在胃癌和大肠癌中的表达与患者年龄有关 ;C -erbB - 2表达与大肠癌分化程度及乳癌恶性程度有关。结论 :C -erbB - 2高表达是大肠癌、乳癌恶性度高 。Objective: To study the expression and the significance of C-erbB-2 in different types in gastric carcinoma colorectal carcinoma and breast carcinoma. Method: The 114 cases of gastric carcinoma 104 colorectal carcinoma and 106 breast carcinoma are collected , then sections are parafined and Sp immulnohischenistry is used. Result: Positive rates of C-erbB-2 in gastric ?colorectal ard breast carcinoma are 71.9% , 57.7% and 54.7% respectively . The expression of C- erbB- 2 in gastric and colorectal carcinoma is correlative with the age of the paients , with differentiation in colorectal carcinoma and malignacy in breast carcinoma as well. Conclusion: The high-expression of C-erbB-2 in colorectal and breast carcinoma is the index which indicates high malignacy and bad progress. [

关 键 词：表达 胃癌 大肠癌 乳腺癌 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]