上颌窦恶性肿瘤组织中p53和PCNA的表达及其意义  

Expression and Significance of p53 and Proliferating Cell Nuclear Antigen in Malignant Tumor of Maxillary Sinus

作　　者：谢汝华[1] 陈直华[1] 陈明远[1] 候景辉[1] 吴剑辉[1] 伍国号[2] 吴秋良[3] 

机构地区：[1]中山大学肿瘤防治中心综合三科 [2]中山大学肿瘤防治中心头颈外科,广东广州510060 [3]中山大学肿瘤防治中心病理科

出　　处：《癌症》2002年第11期1244-1247,共4页Chinese Journal of Cancer

摘　　要：背景与目的:据文献报道,p53和增殖细胞核抗原(proliferatingcellnuclearantigen,PCNA)与恶性肿瘤的发生发展有密切关系,本研究检测p53和PCNA在上颌窦恶性肿瘤、良性肿瘤和炎症性病变中表达的强度差异,探讨p53和PCNA与上颌窦恶性肿瘤临床分期、病理分型及淋巴结转移的关系。方法:用免疫组化的方法检测108例上颌窦恶性肿瘤、19例上颌窦良性肿瘤、8例鼻粘膜炎症中p53和PCNA的表达情况。数据统计采用秩和检验,并用平均秩衡量p53和PCNA的阳性表达强度。结果:在上颌窦良性肿瘤和鼻粘膜炎症两组中,p53和PCNA的平均秩分别为42.8、50.3和47.9、46.8;在恶性肿瘤组中,p53和PCNA平均秩分别高达73.0和73.2;在上颌窦恶性肿瘤中,鳞癌p53的平均秩为60.7,比腺癌的平均秩(43.9)高,有显著性差异(P<0.05)。但临床分期Ⅰ～Ⅳ期中,p53平均秩分别为46.6、50.1、56.1、55.0,PCNA平均秩分别为60.5、48.8、56.1、53.9;在无淋巴结转移组和有淋巴结转移组中,p53平均秩分别为53.7和57.3,PCNA平均秩分别为53.9和56.4;在生存期<3年、<5年和≥5年等3组中,p53平均秩分别为49.9、53.7和48.5,PCNA平均秩分别为45.7、56.9和52.0,均无显著性差异(P>0.05)。结论:p53和PCNA与上颌窦恶性肿瘤尤其是鳞癌的发生、发展有一定相关性。Background & Objective: p53 and proliferating cell nuclear antigen (PCNA) play an important role in the development of malignant tumor. This study was designed to evaluate the role of p53 and PCNA in the development of malignant tumor of maxillary sinus by detecting their expression in malignant, benign, and inflammatory lesions of maxillary sinus. Methods: The expressions of p53 and PCNA were detected by immunohistochemistry in 108 malignant, 19 benign, and 8 inflammatory tissues of maxillary sinus. Rank sum test was used and the levels of positive degree of p53 and PCNA were represented by mean rank. Results: The mean ranks of p53 and PCNA were 42.8 and 47.9 in inflammatory group and 50.3 and 46.8 in benign group, but 73.0 and 73.2 in malignant group, respectively. In malignant group, mean rank of p53 in squamous cell carcinoma (SCC) was 60.7, which was higher than that in adenocarcinoma (43.9). The differences were significant (P< 0.05). While from stage Ⅰ to stage Ⅳ,the mean ranks of p53 were 46.6, 50.1, 56.1, and 55.0 and the mean ranks of PCNA were 60.5, 48.8, 56.1, and 53.9, respectively; The mean ranks of p53 and PCNA were 57.3 and 53.7 in malignant group with lymph nodes metastasis and 56.4 and 53.9 in the group without metastasis, respectively. In the patients with the survival time of< 3 year, < 5year, and ≥5 year, the mean ranks of p53 were 49.9, 53.7, and 48.5 and the mean ranks of PCNA were 45.7, 56.9, and 52.0, respectively. The differences were not significant (P >0.05). Conclusions: p53 and PCNA correlate to the malignant change in maxillary sinus,(especially for SCC), but are not associated with clinical phase, lymph node metastasis, and prognosis of the malignant tumor.

关 键 词：表达 P53 增殖细胞核抗原 上颌窦肿瘤 

分 类 号：R739.62[医药卫生—肿瘤]