肝癌高发区扶绥县主粮中杂色曲霉玉米培养基提取液的遗传毒性  

THE GENOTOXIC EFFECTS OF EXTRACT OF ASPERGILLUS VERSICOLCR GROWN ON THE MAIN GRAINS IN THE HIGH LIVER CANCER INCIDENCE AREA-FUSUI COUNTY.

作　　者：阮萃才[1] 梁远[1] 刘锦玲[1] 刘宗河[1] 涂文升[1] 

机构地区：[1]广西肿瘤防治研究所,南宁530027

出　　处：《癌变．畸变．突变》1992年第2期4-7,共4页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：从肝癌高发的扶绥县主粮中分离出5株杂色曲霉接种于玉米培养基培养并制备其有机提取液,分别用Ames试验、枯草杆菌重组修复试验和原噬菌体诱导检测法对杂色曲霉提取液进行遗传毒性测定。结果5株杂色曲霉提取液均显示不同程度的致突变性,表明肝癌高发县主粮中杂色曲霉产毒株的普遍存在,并提示对肝癌的发病率可能起一定作用。The 5 strains of Aspergillus versicolor were isolated from the main grains in the high liver cancer incidence area-Fusui county.They were inoculated on corn medium, with methanol and trichloromethane extracted repeatedly and their metabolic extracts were prepared, then genotoxity of these extracts with Ames Test、 Becillus subtilis Rec-Assay and Inductest were tested. The results showed that all extracts of A. versicolor had differential mutagenic effects, It suggested that the toxic-producing of A. versicolor was present widespread. It is considered that the toxic meta-bolite of A. versicolor may play an important role for the incidence of liver cancer in Fusui county

关 键 词：遗传毒性 肝肿瘤 杂色曲霉液 

分 类 号：R735.702[医药卫生—肿瘤]