HSV—2(333)对小鼠C型病毒的辅助致癌作用观察  

THE PROMOTIVE EFFECT OF HSV- 2 (333) ON MOUSE C-VIRUS INDUCED LEUKEMIA

作　　者：刘建军[1] 陈敏诲[1] 高又新[1] 张有新[1] 

机构地区：[1]湖北医学院病毒研究所,武汉430077

出　　处：《癌变．畸变．突变》1992年第5期33-34,29,共3页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：HSV—2(333)是一种DNA病素,C型病毒是一种RNA病素。在接种3C型病毒的小鼠中白血病的发生率是41.02％,当用这两种病毒接种小鼠以后,白血病发生率增加到79.16％,单独用HSV—2(333)接种的小鼠和对照组的小鼠无白血病发生。实验结果表明HSV—2(333)对小鼠无致癌作用,它是一种辅助致癌因子。The frequency of leukemia formation on mice inoculated with c-virus, a kind of RNA virus, was 41. 02%. But it increased to 79. 16% when HSV-2 (333), a kind of DNA virus. was inoculated along with c-virus. No leukemia was found in mice inoculated with HSV-2 (333) alone. These observations indicated that HSV-2 (333) was not a carcinogen itself, but a cocancerogen.

关 键 词：HSV-2 C型病毒 白血病 致癌因子 

分 类 号：R730.231.3[医药卫生—肿瘤]