EB病毒诱导下鼻咽癌患者外周血淋巴细胞的转化和退变  

TRANSFORMATION AND REGRESSION OF PREIPHERAL BLOOD MONOLUCLEAR CELLS REINFECTED BY EPSTEIN-BARR VIRUS IN PATIENTS WITH NASOPHARYNGEAL CARCINOMA

作　　者：孙宁[1] 陈小毅[1] 吴枫[1] 唐慰萍[1] 

机构地区：[1]湛江医学院肿瘤研究室病理教研室,湛江524023

出　　处：《癌症》1992年第2期117-119,共3页Chinese Journal of Cancer

摘　　要：已感染EB病毒(EBV)者,如再次用EBV刺激,可出现外周血淋巴细胞转化细胞团的退变。本文观察阳性正常人20例、VCA—IgA阳性鼻咽癌(NPC)病人11例外周血淋巴细胞的这种转化和退变,全部阳性组受试者都出现B淋巴细胞转化,且转化细胞团的退变十分显著,仅少数转化细胞可以传代;而阳性NPC组转化时间提前,转化更完全,但退变出现的时间推迟,程度也较轻。作者认为,转化细胞团的退变,可间接反映特异性杀伤性T淋巴细胞的功能,因此,鼻咽癌病人T细胞免疫功能是降低的。Regression of transformated foci of peripherial blood mononuctear cells was observed in those donors hich were seropositive for EBV VCA-IgA and divided into two groups, normal(20 cases) and nasopharyngeal carcinoma (NPC) patients(11), after EBV reinfection in vitro. It was very obvious in normal people while delayed and slight in NPC patients. Such a regression appears to be the specific T cell cytotoxic ability that decrease of T cell-mediated immunity in NPC must be considered.

关 键 词：淋巴细胞 转化 细胞毒 鼻咽肿瘤 

分 类 号：R739.63[医药卫生—肿瘤]