C-myc及C-Ha-ras-1癌基因在宫颈炎组织中的存在及相互关系  

EXISTENCE AND CORRELATION OF C-HA-RAS-1 AND CMYC ONCOGENES IN CHRONIC CERVICITIS

作　　者：崔正言[1] 孟祥金[1] 孙汭[1] 崔树岺 李文[1] 曲迅[2] 朱长义[2] 邓文[2] 孙玉玲[2] 胡淑仁 

机构地区：[1]山东省医学科学院基础医学研究所,济南520040 [2]泰山医学院 [3]山东省劳改局医院妇产科

出　　处：《癌症》1992年第2期114-116,共3页Chinese Journal of Cancer

基　　金：山东省科委资助项目

摘　　要：应用斑点分子杂交技术检测了87例慢性宫颈炎活检标本中C-myc和C-Ha-ras-l癌基因,结果发现7％的标本中C-ras-l癌基因阳性,13％的标本中C-myc癌基因阳性;并且在6例C-Ha-ras-l阳性的标本中有一半(3例)同时C-myc癌基因也阳性。结果提示,慢性宫颈炎中存在C-myc和C-Ha-ras-l癌基因的激活和扩增,C-myc和C-Ha-ras-l癌基因可能协同作用引起宫颈癌的发生。87 of chronic cervicitis biopsies were detected for the presences of C-Ha-ras-1 and C-myc oncogenes by DNA dot blot hybridization, it was found that 7% of specimens was positive for C-Ha-ras-1 oncogene, and 13% was positive for C-myc oncogene. 3 were also positive for C-myc oncog e among 6 C-Ha-ras-1 oncogene positive specimens. The results indicated activiation and amplification of C-Ha-ras-1 and C-myc oncogenes in chronic cervicitis may exist. C-Ha-ras-1 and C-myc oncogenes may have a synergism in the development of cervicalcancer.

关 键 词：C-MYC 癌基因 宫颈炎 子宫肿瘤 

分 类 号：R737.33[医药卫生—肿瘤]