双β-羧乙基锗倍半氧化物对小鼠和裸鼠移植性肿瘤生长的影响  

THE GROWTH INHIBITORY ACTION OF DI - β - CARBQXYET-HLGERMANIUM SESQUIOXDE(Ge-132) ON TRANSLANTABLE TUMORS IN MICE AND NUDE MICE

作　　者：谢冰芬[1] 杨小平[1] 潘启超[1] 刘宗潮[1] 郭慧艳 张玉华 张柏珍 

机构地区：[1]中山医科大学肿瘤研究所,广州510060 [2]广州半导体材料研究所,广州510060

出　　处：《癌症》1992年第2期94-96,99,共4页Chinese Journal of Cancer

摘　　要：我们研究了双β-羧乙基锗倍半氧化物(Ge—132)的抗瘤作用,结果表明对小鼠Harding—Passey黑色素瘤(M—HP)、艾氏腹水癌实体瘤(ESC)和裸鼠移植人肺鳞癌的生长有明显的抑制作用,并发现Ge—132与DDP合并应用对抗裸鼠移植人肺鳞癌有协同作用。The antitumor activity of carboxyethylgermanium sesquioxide(Ge-132)was studied. The results showed that the Ge-132 possessed the definite inhibitory effect against the growth of Harding-Passey melanoma(M-HP), Ehrlich ascites carcinoma (solid form) (ESC) in mice, and the xenograft of human lung squamous cancer in nude mice. It was found that the combined use of Ge- 132 and DDP can increase the inhibition rate of DDP alone against xenograft of human lung cancer in nude mice.

关 键 词：羧乙基 锗倍半氧化物 黑色素瘤 

分 类 号：R73－352[医药卫生—肿瘤]