AgNOR与宫颈癌病理形态学和临床预后关系的探讨  

STUDY ON NUCLEOLAR ORGANISER REGIONS IN MORPHOLOGY AND PROGNOSIS OF SQUAMOUS ACARCINOMA OF CERVIX

作　　者：何丹[1] 孙维纲[1] 汤如勇[1] 覃质彬 郑锦明[1] 廖传桂[1] 

机构地区：[1]四川省肿瘤医院,成都610041 [2]华西医大附一院病理科

出　　处：《癌症》1992年第4期279-282,共4页Chinese Journal of Cancer

摘　　要：通过对40例宫颈鳞癌和6例鳞化的宫颈上皮进行AgNOR染色,结果发现宫颈鳞癌与鳞化上皮的AgNOR计数有显著差异(P<0.001),并进一步发现AgNOR计数与宫颈癌的组织形态和细胞学分级有关。同时通过对30例有随访资料的宫颈癌病例的AgNOR计数分析,发现在确诊后三年内死亡的17例和仍存活的13例病人的癌组织AgNOR计数有极显著差异(P< 0.001)。讨论了AgNOR计数作为宫颈鳞癌的一项新的临床病理诊断辅助指标的可能性。A total of 40 patients suffering from squamous carcinoma of uterine ce rvix were studied by the method of AgNOR technique. It was found that there was significant difference between the average AgNOR counts in squamatized mucosa of cervix and average in squamous carcinoma of cervex. It was found also that the average AgNOR counts in cytological high grade and histologjcal high grade group was higher than those in low grade group. Meanwhile, during three years following up, it was noticed that there was poorer prognosis in 17 patients with higher AgNOR counts (X= 10,85±2.31), and better prognosis in 13 patients with lower AgNOR counts (X = 8.24± 1.25). This difference was statistically significant (P<0.001). It was suggested that the AgNOR counts may be regarded as a comparatively independent prognostic parameter for squamous carcinoma of cervix.

关 键 词：子宫肿瘤 核仁组成区 病理形态学 

分 类 号：R737.330.4[医药卫生—肿瘤]