肿瘤实验性化疗中核仁形成区(NORs)的观察  

SILVER-BINDING NUCLEOLAR ORGANIZER REGIONS(Ag-NORs) IN THE TUMOR TRANSPLANTED UNDER THE RENAL CAPSULE OF MMUNOSUPPRESSED MICE IN CHEMOSENSITIVITY TEST

作　　者：凌雁[1] 祝庆蕃[1] 付淑丽[1] 窦桂荣[1] 

机构地区：[1]河南医科大学病理学教研室,郑州450052

出　　处：《癌症》1992年第6期448-449,共2页Chinese Journal of Cancer

摘　　要：本实验用免疫抑制鼠肾包膜下移植入食管癌109细胞株实体瘤方法,观察瘤细胞核仁形成区嗜银蛋白(Ag-NOR)在化疗中的变化。石腊切片银染,平阳霉素组平均每个细胞核银染颗粒为1.46±0.03,顺铂组1.39±0.03,对照组1.79±0.08(P<0.05)。提示肿瘤化疗后Ag-NOR计数减少。Using a silver staining technique, nucleolar orgnizer region-associated proteins (Ag-NORs ) have been studied in paraffin sections of the tumor transplanted under renal capsule of immunosuppressed mice. Bleomycin (BLM)and Cis-platini Diaminum-Dichloridumt(DDP)were used as chemotherapentic agents in this study. The Ag-NOR contents of implanted tumors in control group was 1.79±0.08,in tumor treated by BLM was 1.46 ± 0.03, treated by DDP was 1.39 ±0.03(P< 0.05). This indicated that Ag-NOR count of tumor cells decreased after treated by anticancer drugs. The Ag-NOR count of tumor cells in chemosensitivity test may be an indicator of the anti-cancer activity of the drugs.

关 键 词：顺铂 核仁形成区 肿瘤 药物疗法 

分 类 号：R730.53[医药卫生—肿瘤]