Effects of Nicotinamide on Mouse Skin Tumor Development and Its Mode of Action  

作　　者：KRISHNA P. GUPTA(Environmental Carcinogenesis Section, Industrial Toxicology Research Centre,Post Box No- 80, Mahatma Gandhi Mang, Lucknow-226 001, India) 

出　　处：《Biomedical and Environmental Sciences》1999年第3期177-187,共11页生物医学与环境科学（英文版）

摘　　要：Nicotinamide (NA), a naturally occuring vitamin and a protease inhibitor, has been shown to be effective in treating some skin ailments. It inhibits cell proiferaion and induces cell differentiation. This report shows the effects of NA on mouse skin tumor development and on the critical events involved in this process. NA reduced tumor growth, inhibited the 12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase activity, but induced the transglutaminare activity which was inhibited by TPA under different experimental conditions.The effects of NA on ornithine decarboxylare (ODC) and transglutaminase (TG) indicated that nicotinamide (NA) probably programmmed the cells for their death in the natural course of time, i.e. programed cell death. This observation indicates that NA might be a better agent for the detailed study and for the better use in prevention of cancer alone or in combination with other drugs.Nicotinamide (NA), a naturally occuring vitamin and a protease inhibitor, has been shown to be effective in treating some skin ailments. It inhibits cell proiferaion and induces cell differentiation. This report shows the effects of NA on mouse skin tumor development and on the critical events involved in this process. NA reduced tumor growth, inhibited the 12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase activity, but induced the transglutaminare activity which was inhibited by TPA under different experimental conditions.The effects of NA on ornithine decarboxylare (ODC) and transglutaminase (TG) indicated that nicotinamide (NA) probably programmmed the cells for their death in the natural course of time, i.e. programed cell death. This observation indicates that NA might be a better agent for the detailed study and for the better use in prevention of cancer alone or in combination with other drugs.

关 键 词：Apoptosis ANIMALS FEMALE Mice NIACINAMIDE Ornithine Decarboxylase Research Support  Non-U.S. Gov't Skin Neoplasms Tetradecanoylphorbol Acetate TRANSGLUTAMINASES 

分 类 号：R739.5[医药卫生—肿瘤] R730.231[医药卫生—临床医学]