羟基喜树碱联合阿糖胞苷治疗高危慢性粒细胞白血病观察  

CLINICAL EFFECTS OF CA PROTOCOL ON CHRONIC GRANULOCYTE LEUKEMIA IN HIGH-RISK GROUP

作　　者：杜庆锋[1] 刘晓力[1] 周淑芸[1] 宋兰琳[1] 李荣[1] 牛京娜[1] 萧益惠 邱信葵 

机构地区：[1]第一军医大学南方医院血液科 [2]江苏省仪征市人民医院血液科 [3]广东省东芜市石龙镇人民医院内1科

出　　处：《中国现代医学杂志》2002年第20期42-43,46,共3页China Journal of Modern Medicine

摘　　要：目的 :探讨羟基喜树碱联合阿糖胞苷 (CA)方案治疗高危组慢性粗细胞白血病 (CGL)的近、远期临床疗效。方法 :用CA方案治疗 18例Sokal危险指数 >1.2的慢性期高危组CGL ,观察其近远期临床疗效并与羟基脲 (Hu) +CS30 0 0单采治疗组进行对比 ;观察病人染色体治疗前后的Ph阳性细胞百分率变化情况。结果 :CA组获CR4例 (2 2 .2 % ) ,PR 6例 (33.3% ) ,总有效率为 5 5 .5 % ,1例病人获轻度细胞遗传学反应 :对照组无人CR(0 % ) ,PR 5例 (2 2 .7% ) ,总有效率 2 2 .7% ,无病人获细胞遗传学反应 ;两组间CR率及有效率均存在统计学差异 ,P <0 .0 5。CA组病人平均、中位生存期 (32 .2月、30 .0月 )稍长于对照组 (2 9.7月、2 8.0月 ) ,但无统计学差异 (P >0 .0 5 )。该方案毒副反应轻 ,病人耐受良好。结论 :羟基喜树碱联合阿糖胞苷治疗高危慢性期慢性粒细胞白血病有一定疗效 ,值得进一步在临床中观察和总结。Objective:To explore the clinical effect of the combination of hydroxy-Camptothecine and Ara-C (CA protocol)on high-risk group patients with chronic granulocyte leukemia(CGL).Methods: Eighteen cases of chronic myeloid leukemia patients in high-risk group were treated with the CA protocol from 1993 to 1998. The recent and long-term clinical effect were observed, and the cytogenetic response as well.Results:Four patients (22.2%)achieved complete remission(CR) and 6(33.3%) partial remission(PR),and cytogenetic response was observed in one patient in CR. All patients were well tolerated with this protocol and no severe side reaction was observed.Conclusions:CA protocol has showed some effect on CML inbe investigated and used high-risk group and is worthwhile to be investigated and used in clinic.

关 键 词：羟基喜树碱 阿糖胞苷 治疗 高危慢性粒细胞白血病 联合治疗 

分 类 号：R733.72[医药卫生—肿瘤] R730.53[医药卫生—临床医学]