口腔粘膜鳞癌中C-myc和nm23-H_1蛋白的表达研究  

Study on the expressions of C-myc and nm23-H_1 proteins in oral squamous cell carcinomas

作　　者：赵洪伟[1] 谢文扬[1] 邓飞[2] 

机构地区：[1]遵义医学院附属口腔医院颌面外科 [2]遵义医学院附属医院病理科,贵州遵义563003

出　　处：《遵义医学院学报》2002年第4期310-312,共3页Journal of Zunyi Medical University

基　　金：贵州省卫生厅科学基金资助项目 (NO :D - 15 6 )

摘　　要：目的　研究口腔粘膜鳞癌组织中C myc和nm2 3 H1蛋白的表达及意义。方法　采用免疫组化方法检测79例口腔粘膜鳞癌组织中C myc和nm2 3 H1蛋白的表达状况。结果　口腔粘膜鳞癌组织中C myc蛋白的强阳性表达率为 6 3.3% (5 0 / 79) ,nm2 3 H1蛋白的强阳性表达率为 35 .4 % (2 8/ 79) (P <0 .0 5 )。颈淋巴结有转移者较无转移者C myc蛋白的强阳性表达率高 ,而nm2 3 H1蛋白的强阳性表达率低。结论　C myc和nm2 3 H1蛋白的表达状况与口腔粘膜鳞癌颈淋巴结转移有关。Objective To investigate the expressions of C-myc and nm23-H 1 proteins in cancer tissue of patients with oral squamous cell carcinomas (OSCCs).Methods Immunohistochemistry was used to detect the status of C-myc and nm23-H 1 proteins' expressions in 79 cases of OSCCs.Results Among these cases, the extremely positive rate of C-myc and nm23-H 1 were 63.3%(50/79) and 35.4%(28/79) respectively (P<0.05). The extremely positive rate of C-myc protein in the patients with lymph node metastasis is higher than those with negative metastasis .On the contrary, the extremely positive rate of nm23- H 1 protein is lower.Conclusions Lymph node metastasis might be correlated with high level expression of C-myc protein and low level expression of nm23-H 1 protein in OSCCs.

关 键 词：C-MYC NM23-H1 口腔粘膜肿瘤 鳞癌 基因 免疫组化 

分 类 号：R739.85[医药卫生—肿瘤]