细胞间黏附分子-1和碱性成纤维细胞生长因子在脑梗死中的作用  

Change of serum soluble intercellular adhesion molecule and basic fibroblast grouth factor in patients with acute cerebral infarction and its clinical significance

作　　者：宋水江[1] 闻树群[1] 黄鉴政[1] 丁德云[1] 郑晓红[2] 

机构地区：[1]浙江大学医学院附属第二医院神经内科,杭州310009 [2]杭州铁路医院内科

出　　处：《中华医学杂志》2002年第21期1447-1449,共3页National Medical Journal of China

摘　　要：目的　了解脑梗死急性期血清可溶性细胞间粘附分子 1 (sICAM 1 )和碱性成纤维细胞生长因子 (bFGF)含量的变化及它们在脑梗死发生发展过程中的作用。方法　采用酶联免疫吸附法(ELISA)检测 55例急性期脑梗死患者和 32例其他疾病对照组患者及 30例健康人为对照组 ,测量血清sICAM 1和bFGF含量。结果　 (1 )脑梗死患者血清sICAM 1和bFGF含量分别为 766 2 μg L± 1 78 8μg L和 1 7 4μg L± 8 2 μg L ,高于其他疾病对照组 (52 9 6μg L± 76 7μg L和 8 3μg L± 2 8μg L) ,正常健康对照组 (52 0 7μg L± 1 1 5 9μg L和 5 8μg L± 2 7μg L) ,差异有显著意义 (P =0 0 0 0 )。 (2 )相关分析 :脑梗死时血清sICAM 1含量与bFGF含量呈正相关 (r=0 471 ,P =0 0 0 0 ) ,与外周血白细胞数呈正相关 (r=0 2 85 ,P =0 0 35) ,与神经功能缺损评分呈负相关 (r=- 0 333 ,P =0 0 1 3) ,而与血脂水平无明显相关关系 (胆固醇r=- 0 0 4 2 ,P =0 758;甘油三酯r =0 0 61 ,P =0 657)。 (3)脑梗死患者血清sICAM 1和bFGF含量与高血压史关系不密切。而bFGF含量与病灶大小有关。结论　ICAM 1和bFGF可能通过炎症机制参与了脑梗死的病理生理过程 ;急性期监测血清sICAMObjective To explore the changes of the levels of soluble intercellular adhesion molecule 1(sICAM 1) and basic fibroblast growth factor (bFGF) in serum of patients with acute cerebral infarction,and the effects of sICAM 1 and bFGF on cerebral infarction Methods ELISA was used to detect the serum sICAM 1 and bFGF of 55 patients with acute cerebral infarction(within 2 days) as well as 32 patients diagnosed as with other neurologic diseases(20 patients with sciatica and 12 with trigeminal neuralgia) and 30 healthy persons as controls Results (1) Both serum sICAM 1 and bFGF in the infarction group were significantly higher [(766 2±178 8) μg/L and (17 4±8 2) μg/L respectively] than in other disease control group [(529 6±76 7) μg/L and (8 3± 2 8) μg/L respectively] and normal control group [(520 7±115 9) μg/L and (5 8±2 7) μg/L respectively] ( P =0 000) (2) Correlation analysis showed that there was a positive correlation between the level of serum sICAM 1 and bFGF ( r =0 471, P =0 000),the level of sICAM 1 was also positively correlated with the number of leukocytes at acute stage ( r =0 285, P =0 035), and a negative correlation between sICAM 1 and European stroke scale ( r =-0 333, P =0 013) was found No significant correlation was observed between the level of sICAM 1 and the levels of serum cholesterol ( r =-0 042, P =0 758) or triglyceride ( r =0 061, P =0 675) (3) Blood pressure seemed to have no influence on the content of sICAM 1 and bFGF after cerebral infarction, while the level of serum bFGF with large infarct size was obviously higher at acute stage Conclusion The levels of sICAM 1 and bFGF increase significantly in the patients with acute cerebral infarction sICAM 1 and bFGF mayin participate in the pathophysiologic process through inflammatory mechanism The detection of serum sICAM 1 will be helpful in estimating the clinical severity and the determinate of bFGF will be helpful in estimating the size of in

关 键 词：脑梗死 细胞间粘附分子-1 碱性成纤维细胞生长因子 

分 类 号：R743.33[医药卫生—神经病学与精神病学]