河南食管癌高发区青年食管癌患者食管鳞癌组织雌激素和孕激素受体的表达  

Alterations of estrogen and progesterone receptors expression in esophageal squamous cell carcinoma from the young adults at high-incidence area for esophageal cancer in Henan

作　　者：王启鸣[1] 王立东[1] 孙超[1] 庄则豪[1] 安继业[1] 范宗民[1] 郭花芹[1] 高珊珊[1] 丁忠华[1] 焦新英 李吉林 

机构地区：[1]郑州大学医学院癌症研究室,郑州450052 [2]林州市姚村食管癌医院病理科,林州456592

出　　处：《郑州大学学报（医学版）》2002年第6期755-758,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：国家杰出青年科学基金 3 0 0 2 5 0 16;河南省高校创新人才工程基金;河南省医药卫生创新人才工程基金资助项目

摘　　要：目的 :探讨河南食管癌高发区青年食管癌患者 (≤ 4 0岁 )食管鳞癌组织中雌激素受体 (ER)和孕激素受体 (PR)的表达变化特征。方法 :采用免疫组织化学ABC法 ,检测 4 3例高发区青年食管癌患者手术切除标本ER和PR表达变化。结果 :高发区青年食管癌患者食管癌组织中雌激素受体阳性率为 4 7% ,孕激素受体的阳性率为7 %。ER、PR阳性率与组织分化程度、性别、淋巴结转移无关。结论 :食管癌高发区青年食管癌患者癌组织中有较高的ER表达 ,而PR阳性表达明显低于ER ,提示ER变化是青年食管癌患者频发的分子事件 ,进一步了解血清和组织雌、孕激素水平和ER的变化关系 。Aim: To characterize the expression of estrogen and progesterone receptors (ER and PR) in esophageal squamous cell carcinoma (SCC) from the young adults in high incidence area for esophageal cancer. Methods: Immununohistochemical method (ABC) was used to determine the expression of ER and PR of SCC from the young adults ( n =43). Results: The positive immunostaining rates for ER and PR in the young adult patients were 47% and 7%, respectively. The immunostaining activity did not correlate with differentiation,sex,and lymph node metastasis. Conclusion: The present studies identify that the high frequency of ER expression in the young adult EC patients, and low level of PR, indicating that alteration of ER was one of the common molecular events in the young adult EC patients. It is worthy of further correlating the changes of ER in the blood and tissue.

关 键 词：河南 食管部 高发区 青年 食管鳞癌组织 雌激素受体 孕激素受体 

分 类 号：R735.1[医药卫生—肿瘤]