联合检测血清中CYFRA21-1、NSE对肺癌诊断和预后的意义  

The Role of the Assay of CYFRA21-1 and NSE in Serum in the Diagnosis and Prognosis Lung Cancer

作　　者：李承红[1] 杨军[1] 马丹[1] 叶舟[1] 夏筱娟[1] 吉冬元[1] 林榕[1] 许立天[1] 

机构地区：[1]江汉大学附属医院内科,湖北武汉430015

出　　处：《江汉大学学报（医学版）》2002年第3期18-21,共4页Journal of Wuhan Professional Medical College

基　　金：武汉市科委项目 (wk) 2 0 0 2 10 0 1

摘　　要：目的 :评价肿瘤标记物CYFRA2 1- 1、NSE对肺癌诊断和预测预后的价值。方法 :将肺癌患者分为非小细胞性肺癌组 (NSCLC)和小细胞性肺癌组 (SCLC) ,良性疾病患者为对照组。采静脉血 ,按RIA方法检测CYFRA2 1- 1、NSE。采用STATA统计软件进行结果分析。结果 :CYFRA2 1- 1水平在NSCLC中明显高于SCLC和良性疾病患者 ,分别为 15 .45± 4.0 1、6.14± 3 .88、1.86± 0 .89。NSE则在SCLC中显著高于NSCLC和良性疾病组 ,分别为 3 .90± 1.47、2 .65± 1.47、2 .16± 0 .74。CYFRA2 1- 1、NSE联合检测与各单项指标相比 ,正确率增高 (P <0 .0 1) ,而且NSE是提示SCLC预后的有价值的指标 ,CYFRA2 1- 1则是提示NSCLC预后的有价值的指标。结论 :联合检测血清中CYFRA2 1- 1、NSE的含量诊断肺癌的阳性率最高 ,准确性达 87.41% ,同时显示 ,NSE、CYFRA2 1- 1分别是提示SCLC、NSCLC预后的有价值的独立指标 。Objective: To evaluate the diagnostic performance and prognostic role of the cancer marker CYFRA21-1 and NSE in the lung cancer.Methods:This study included three groups: one group with non small cell lung cancer, one group with small cell lung cancer and a control group with benign lung disease. venous samples were collected. The concentration of CYFRA21-1 and NSE were determined using RIA method. The results were analyzed using the STATA statistic software.Results: The CYFRA21-1 levels in venous in the group with NSCLC was significantly higher than those in the group with SCLC and benign lung disease(the levels of the three groups in serum are 15.45±4.01 , 6.14 ± 3.88 , 1.86 ± 0.89 ). The NSE levels in venous in the group with SCLC was significantly higher than those in the group with NSCLC and benign lung disease (the levels of the three groups in serum are 3.90 ± 1.47 , 2.65 ± 1.47 , 2.16 ± 0.74 ). Compared with the single parameter, the accuracy is increased when combining the assay of CYFRA21-1 and NSE ( P < 0.01 ).NSE have prognostic significance in SCLC, CYFRA21-1 have prognostic significance in NSCLC.Conclusion: The sensitivity is the highest to the diagnosis of lung cancer when combining CYFRA21-1 and NSE in serum, and its accuracy is 87.41% . NSE in SCLC is an independent prognostic factor and CYFRA21-1 in NSCLC is an independent prognostic factor. They may be proposed for use in the clinic and research.

关 键 词：联合检测 血清 CYFRA21-1 NSE 肺癌 诊断 预后 

分 类 号：R734.2[医药卫生—肿瘤]